• 专利附录
  • 专利说明
  • 权利要求
  • 类似技术
  • 同族专利
  • 引用文献
  • 法律状态
  • 优先权
    • 专利摘要:
    Apparatus and methods are provided for use in sealing a vascular puncture site. The invention comprises an introducer sheath with an integrated closure component. The closure component includes an advanceable resilient spring clip with an expanded delivery configuration in which opposing sides do not contact one another, and an unstressed deployed configuration, in which opposing sides close towards one another. The clip is advanced along the sheath until it pierces opposing sides of a vessel wall at a puncture site. The sheath then is withdrawn, thereby causing the clip to resiliently return to its unstressed deployed configuration and draw opposing sides of the puncture together to seal the wound.
    公开号:US20010007077A1
    申请号:US09/764,813
    申请日:2001-01-16
    公开日:2001-07-05
    发明作者:Richard Ginn；William Aldrich
    申请人:Medical Technology Group Inc；
    IPC主号:A61B17-10
    专利说明:
    [0001] The present invention relates to apparatus and methods for sealing an iatrogenic puncture in a vessel formed in conjunction with a diagnostic or therapeutic treatment. More particularly, the present invention provides apparatus comprising an introducer sheath including a puncture site closure device comprising an expandable clip with elastic memory. [0001] BACKGROUND OF THE INVENTION
    [0002] Catheterization and interventional procedures, such as angioplasty and stenting, generally are performed by inserting a hollow needle through a patient's skin and muscle tissue into the vascular system. A guide wire then is passed through the needle lumen into the patient's blood vessel. The needle is removed and an introducer sheath is advanced over the guide wire into the vessel. A catheter typically is passed through the lumen of the introducer sheath and advanced over the guide wire into position for a medical procedure. The introducer sheath therefore facilitates insertion of various devices into the vessel while minimizing trauma to the vessel wall and minimizing blood loss during a procedure. [0002]
    [0003] Upon completion of the medical procedure, the catheter and introducer sheath are removed, leaving a puncture site in the vessel. Commonly, external pressure is applied until clotting and wound sealing occurs. However, this procedure is time consuming and expensive, requiring as much as an hour of a physician's or nurse's time, is uncomfortable for the patient, and requires that the patient be immobilized in the operating room, cathlab, or holding area. Furthermore, a risk of hematoma exists from bleeding prior to hemostasis. [0003]
    [0004] Various apparatus have been developed for percutaneously sealing a vascular puncture by occluding or suturing the puncture site. For example, U.S. Pat. Nos. 5,192,302 and 5,222,974 to Kensey et al., describe the use of a biodegradable plug delivered through the introducer sheath into the puncture site. When deployed, the plug seals the vessel and provides hemostasis. Such devices have been slow to gain acceptance in the medical community, however, due to difficulties encountered in positioning the plug within the vessel. Moreover, the agents used to occlude the puncture site are animal-derived, typically collagen-based. Thus, a risk of adverse immunoresponse exists. [0004]
    [0005] Another previously known technique comprises percutaneously suturing the puncture site with specialized apparatus. Such apparatus is described, for example, in U.S. Pat. No. 5,304,184 to Hathaway et al. While percutaneous suturing devices may be effective, a significant degree of skill may be required on the part of the practitioner. Because such devices are mechanically complex, they tend to be relatively expensive to manufacture. [0005]
    [0006] Surgical staples and resilient clips for external skin wound closure are well known in the art, Examples include U.S. Pat. No. 5,026,390 to Brown and U.S. Pat. No. 5,683,405 to Yacoubian et al, which both describe resiliently deformable closure devices suitable for manual external application. [0006]
    [0007] To reduce the cost and complexity of percutaneous puncture closure devices, such devices employing resilient clips or staples have been developed. U.S. Pat. No. 5,478,354 to Tovey et al. describes the use of resilient clips in conjunction with a trocar to close abdominal puncture wounds. U.S. Pat. No. 5,810,846 to Virnich et al. describes a specialized apparatus for closing a vascular puncture site with a plastically deformable clip. The apparatus preferably is advanced over a guide wire through a cannula to the surface of the puncture site, where the staple-like clips are delivered to close the wound. [0007]
    [0008] U.S. Pat. No. 5,782,861 to Cragg et al. describes specialized apparatus for closing a puncture site with a detachable clip. The apparatus comprises a hollow shaft, having a distal end formed with one or more opposed pairs of resilient grasping prongs, that is advanced over a guide wire through a coaxial hollow tube to a position at the distal end of the tube just proximal of the puncture. [0008]
    [0009] The grasping prongs are extended beyond the distal end of the tube to grasp the vessel on opposing sides of the puncture. The shaft then is partially retracted, causing the prongs to contract within the tube, thereby sealing the puncture site. Both of the devices described in the foregoing patents have the drawback that a separate device must be deployed through the introducer sheath to close the puncture site, thus prolonging the procedure. Moreover, both devices require relatively complex apparatus and involve time consuming manipulation to achieve hemostasis. [0009]
    [0010] In view of the foregoing, it would be desirable to provide apparatus and methods suitable for vascular puncture closure that overcome the disadvantages of previously known devices. [0010]
    [0011] It also would be desirable to provide apparatus and methods for vascular puncture closure that quickly and effectively achieve hemostasis. [0011]
    [0012] It further would be desirable to provide vascular puncture closure apparatus and methods that do not require the introduction of additional apparatus at the completion of the catheterization procedure to achieve closure. [0012]
    [0013] It still further would be desirable to provide apparatus and methods suitable for vascular puncture closure that do not introduce animal-derived material into the bloodstream. [0013]
    [0014] It would be desirable to provide vascular puncture closure apparatus and methods that are safe, lower cost, and easy to use. [0014] SUMMARY OF THE INVENTION
    [0015] In view of the foregoing, it is an object of the present invention to provide vascular puncture closure apparatus and methods that overcome disadvantages of previously known devices. [0015]
    [0016] It also is an object of this invention to provide apparatus and methods suitable for vascular puncture closure that quickly and effectively achieve hemostasis. [0016]
    [0017] It is a further object of the present invention to provide apparatus and methods for vascular puncture closure that do not require the introduction of additional apparatus at the completion of the catheterization procedure to achieve closure. [0017]
    [0018] It is another object of this invention to provide vascular puncture closure apparatus and methods that do not introduce animal-derived material into the bloodstream. [0018]
    [0019] It is yet another object of the present invention to provide vascular puncture closure apparatus and methods that are safe, lower cost, and easy to use. [0019]
    [0020] These and other objects of the present invention are accomplished by providing a vascular introducer sheath having an integrated wound closure component. The closure component consists of a resilient spring clip disposed on and advanceable over the exterior of the introducer sheath in an expanded delivery configuration until opposite sides of the clip pierce a vessel on opposite sides of a puncture site. The introducer sheath is then withdrawn, enabling the spring clip to contract to its unstressed deployed configuration, thereby drawing opposite sides of the puncture together and closing the wound. Means also are provided for confirming when the spring clip has engaged the vessel wall, thereby indicating to the surgeon that the clip may be deployed and the introducer sheath may be withdrawn. Alternative embodiments of the spring clip also are provided. [0020]
    [0021] Advantageously, the closure component is inexpensively integrated into a standard introducer sheath, thereby eliminating the need for a separate closure device at the conclusion of a catheterization procedure. The present invention provides a quick, safe, effective and easy-to-use technique for wound closure that overcomes drawbacks of previously known devices. Methods of using the apparatus of the present invention also are provided. [0021] BRIEF DESCRIPTION OF THE DRAWINGS
    [0022] The above and other objects and advantages of the present invention will be apparent upon consideration of the following detailed description, taken in conjunction with the accompanying drawings, in which like reference characters refer to like parts throughout, and in which: [0022]
    [0023] FIG. 1 is a side view of a vascular device constructed in accordance with the present invention; [0023]
    [0024] FIG. 2 is a cross sectional view of the closure component of the vascular device of FIG. 1; [0024]
    [0025] FIGS. [0025] 3A-3D are side views of the resilient clip of the present invention shown from different angles in an expanded delivery configuration and in an unstressed deployed configuration;
    [0026] FIGS. 4A and 4B are isometric views of an alternative embodiment of the resilient surgical clip, constructed in accordance with the present invention and shown, respectively, in an unstressed deployed configuration and in an expanded delivery configuration; and [0026]
    [0027] FIGS. [0027] 5A-5F are side-sectional views of a vascular puncture site, illustrating a method of sealing the puncture site with the integrated vascular device of FIG. 1. DETAILED DESCRIPTION OF THE INVENTION
    [0028] The integrated vascular introducer sheath with closure component of the present invention overcomes disadvantages associated with previously known methods and apparatus for sealing a vascular puncture by providing a quick, simple, safe, lower cost, effective, and easy-to-use solution to wound closure. Apparatus constructed in accordance with the present invention provide vascular introduction and wound closure in a single device, eliminating the time and manipulation required to insert a separate closure device at the completion of a procedure. [0028]
    [0029] Referring to FIG. 1, vascular device [0029] 10 comprises introducer sheath 12 coupled to hub 14, clip housing 16, and clip actuator 18.
    [0030] Introducer sheath [0030] 12 comprises a material typically used for vascular introducer sheaths, such as polyethylene or nylon, and includes central lumen 13 through which other devices may be introduced in the vasculature, for example, to perform a diagnostic or interventional procedure such as angiography, angioplasty or stenting.
    [0031] Hub [0031] 14 is mounted to the proximal end of introducer sheath 12 and includes side port 20, arc-shaped lumens 22, backbleed lumens 24, backbleed tubes 25, and device port 26. Device port 26 communicates with central lumen 13 of introducer sheath 12, and has self-sealing elastomeric membrane 27 disposed across it. Self-sealing membrane 27, which may comprise, e.g., latex or a biocompatible synthetic rubber, permits interventional devices to be introducer through device port 25 while preventing blood loss through central lumen 13. Side port 20 of hub 14 is in communication with central lumen 13, and is connected to hemostatic port 34 via biocompatible tubing 36.
    [0032] Clip housing [0032] 16 includes an annular-shaped chamber that holds a elastically deformable clip. In accordance with the principles of the present invention, clip housing is slidably disposed on the exterior of introducer sheath 12 and is movable from a stowed position, adjacent hub 14, to a distal clip deployment position, where the spring clip is urged into engagement with tissue surrounding vascular puncture.
    [0033] Clip actuator [0033] 18 comprises plunger 28 and rods 30, which are configured to slidably pass through arc-shaped lumens 22 of hub 14. The distal ends of rods 30 are mounted in clip housing 16, so that movement of plunger 28 causes corresponding proximal or distal movement of clip housing 16. As described in detail hereinafter, when plunger 28 is moved to its proximal-most position, clip housing is disposed adjacent to hub 14 and provides adequate clearance for interventional devices to be inserted device port 25 and central lumen 13 into the patient's vasculature. When moved to its distal-most position, plunger 28 causes rods 30 to urge clip housing 16 distally.
    [0034] Referring now also to FIG. 2, the closure component of vascular device [0034] 10 is described in greater detail. Clip housing 16 comprises bore 38 that slidably receives introducer sheath 12, bores 40 in which rods 30 are mounted, and backbleed indicator ports 42. Backbleed indicator ports 42 are coupled to backbleed tubes 25 via lumens 44. Housing 16 further comprises threaded bore 46 with male thread 48 and proximal ledge 50, and clip bore 52 with proximal ledge 54. Threaded bore 46 engages female thread 56 of clip expander 58. Clip expander 58 is slidably disposed on introducer sheath 12, and together with the portion of clip housing 16 surrounding the spring clip 62 forms annular chamber 60.
    [0035] Spring clip [0035] 62 is stored in its expanded delivery configuration in annular chamber 60 so that it slidably passes over clip expander 58 until it abuts proximal ledge 54 of clip bore 52. In a delivery configuration of vascular device 10, the length of annular chamber 60, as measured from the distal end of clip expander 58 to proximal ledge 54, extends within the distal end of clip housing 16 for a sufficient distance to cover the length of clip 62. In this manner, clip housing 16 prevents snagging spring clip 62 from snagging on tissue during advancement of clip housing 16 to its deployed position, as described hereinbelow.
    [0036] Rods [0036] 30 pass through arc-shaped lumens 22 of hub 14 and mounted in bores 40 of clip housing 16. Distal advancement of rods 30 causes clip housing 16, expander 58, and spring clip 62 to advance distally a corresponding distance relative to introducer sheath 12. When plunger 28 is moved to its distal-most position, rods 30 may be rotated within arc-shaped lumens 22 to rotate and advance clip housing 16 relative to clip expander 58. This motion causes clip housing 16 to advance distally along female thread 56 of clip expander 58 until the proximal end of the clip expander contacts proximal ledge 50 of threaded bore 46. Further rotation of rods 30 causes proximal ledge 54 to urge a tissue-engaging portion of spring clip 62 distally off of clip expander 58. With clip housing 16 positioned at a vascular puncture site P, rotation of rods 30 causes the tissue-engaging portion, illustratively spikes, to pierce the vessel wall, as seen in dotted profile in FIG. 2.
    [0037] In alternative embodiments, plunger [0037] 28 and rods 30 may be removably coupled to clip housing 16, to permit unobstructed access to device port 26. In this embodiment, rods 30 may include teeth that may be rotated to fixedly engage bores 40 in clip housing 16.
    [0038] As discussed hereinabove, backbleed indicator ports [0038] 42 are coupled to tubes 25 via blood lumens 44 that extend through clip housing 16. Backbleed tubes 25 are slidably disposed through backbleed lumens 24 of hub 14. When the distal end of clip housing 16 is advanced distally against the vessel wall at puncture P, blood enters blood indicator ports 42 and exits tubes 25, providing visual confirmation to the surgeon that the distal end of clip housing 16 is positioned adjacent to the vessel wall. Backbleed tubes 25 thus enable the surgeon to determine when clip housing 16 has been advanced sufficiently to permit clip deployment, while reducing the risk that the clip is either deployed short of the puncture site or extended into the vessel.
    [0039] Still referring to FIG. 1, in conjunction with clip deployment, a bioglue or tissue sealant may be delivered through hemostatic port [0039] 34, tubing 36, port 20 and central lumen 13 of introducer sheath 12 to vascular puncture P to further help seal the vessel after deployment of clip 62. Alternatively, the bioglue or tissue sealant may be delivered through the backbleed path described above.
    [0040] Referring now to FIGS. [0040] 3A-3D, an illustrative spring clip 62 constructed in accordance with the principles of the present invention is described in greater detail. FIG. 3B is a side view of the clip of FIG. 3A rotated 90 degrees, wherein clip 62 is in an expanded delivery configuration. Clip 62 comprises an annular device having upper members 70 joined to lower members 72 by legs 74 to form lumen 80. Outer spikes 76 and inner spikes 78 are connected to lower members 72, and act as elongated tissue-engaging members. Clip 62 is elastically expanded by advancing introducer sheath 12 or clip expander 58 through lumen 80.
    [0041] Upon removal of the introducer sheath, spring clip [0041] 62 resiliently returns to its unstressed deployed configuration, illustrated in FIGS. 3C and 3D, where FIG. 3C corresponds to the view of FIG. 3A and FIG. 3D corresponds to the view of FIG. 3B. When removed from the exterior of introducer sheath 12, spring clip 62 resumes its deployed shape, in which the opposing sides of the clip come together until lower members 72 contact one another, and outer spikes 76 cross inner spikes 78. As depicted in FIG. 3A, clip 62 also may optionally comprise engagement means 77 to securely engage the vessel being closed. Engagement means 77 may, for example, comprise barbs or hooks.
    [0042] Clip [0042] 62 is preferably fabricated from a superelastic material, such as a nickel-titanium alloy, but may comprise any material with sufficient resilience to elastically expand for delivery over sheath 12 and fit within annular chamber 60 of clip housing 16. Clip 62 also may be fabricated from a bioabsorbable material or a combination bioabsorbable and elastically expandable material.
    [0043] FIGS. 4A and 4B illustrate an alternative embodiment of the resilient spring clip of the present invention, wherein clip [0043] 90 comprises hoop 92 and opposing spikes 94. In FIG. 4A, clip 90 is depicted in the unstressed, deployed configuration, in which opposing spikes 94 contact one another, whereas in FIG. 4B clip 90 is depicted in the expanded, delivery configuration, in which opposing spikes 94 are separated by gap 96. Clip 90 is elastically expanded in a manner similar to clip 62 by advancement over introducer sheath 12, and preferably also is fabricated from the materials described hereinabove.
    [0044] Referring now to FIGS. [0044] 5A-5F, in conjunction with FIGS. 1-3, methods of using vascular device 10 are described. In FIG. 5A, introducer sheath 12 has been advanced through skin, fat, and muscle tissue T into vessel V, through vascular puncture P, which is formed in accordance with well-known techniques. With plunger 28 and rods 30 in the proximal-most, fully retracted position, an interventional procedure then is performed by introducing one or more interventional devices, e.g. angioplasty balloons, stent delivery systems, atherectomy devices, etc., through device port 26 and lumen 13 of introducer sheath 12 in accordance with well-known techniques. Side port 20 may be used to infuse fluids, e.g., contrast agents or medications, into the vessel through introducer sheath 12 during the interventional procedure.
    [0045] Upon completion of the procedure, vascular device may be advantageously used to close vascular puncture P. At this point, clip actuator [0045] 18, housing 16, clip expander 58, and clip 62 are disposed in the proximal-most position adjacent to hub 14, as depicted in FIG. 5A.
    [0046] As illustrated in FIG. 5B, clip actuator [0046] 18 then is advanced by urging plunger 28 in the distal direction, thus causing rods 30 to slide through arc-shaped lumens 22 of hub 14 and advance clip housing 16. Continued distal advancement of plunger 28 causes the distal end of clip housing 16 to abut against the exterior of the vessel, so that back bleed indicator ports 42 of clip housing 16 directly communicate with the puncture wound. The presence of pressure in the vessel higher than atmospheric pressure causes blood to pass through indicator ports 42, blood lumens 44, and exit through the proximal ends of tubes 25, thus confirming that clip housing 16 is positioned at the puncture site and should not be advanced further.
    [0047] In FIG. 5C, with clip housing [0047] 16 held immobile, clip actuator 18 is rotated clockwise within arc-shaped lumens 22 so that rods 30 rotate and advance clip housing 16 with respect to clip expander 58 (see FIG. 2). Specifically, ledge 54 of housing 16 contacts the proximal end of clip 62 and drives the clip distally so that its tissue-engaging members, spikes 76 and 78, contact and pierce the wall of vessel V at points around the puncture site, as discussed hereinabove with respect to FIG. 2.
    [0048] Once the spikes have pierced the vessel wall, clip actuator [0048] 18 is rotated counterclockwise within arc-shaped lumens 22 to retract clip housing 16, via threaded bore 46, along clip expander 58. The tissue-engaging members of clip 62 retain the clip within the wall of vessel V while the housing retracts, as shown in FIG. 5D.
    [0049] In FIG. 5E, with clip [0049] 62 engaged with the vessel wall, clip housing 16 and clip expander 58 are withdrawn proximally by proximally withdrawing actuator 18, thereby causing clip 62 to slide off of clip expander 58. In FIG. 5E, spike 78 is embedded in tissue not shown, because that tissue lies within the plane of the cross section.
    [0050] Vascular device [0050] 10 then is withdrawn from the vessel wall. Once introducer sheath 12 is removed from lumen 80 of clip 62, the clip rotates relative to the vessel wall, as shown in FIG. 5F, and returns to its unstressed, deployed configuration, thus drawing opposite sides of puncture P together to seal the puncture. At this point, a suitable biocompatible bioglue or tissue sealant optionally may be injected into the puncture tract, as discussed hereinabove, through device port 26 or side port, to aid in sealing vascular puncture P. Alternatively, the bioglue or tissue sealant may be delivered through the backbleed path described above.
    [0051] Although preferred illustrative embodiments of the present invention are described above, it will be evident to one skilled in the art that various changes and modifications may be made without departing from the invention. For example, with minor modifications, vascular device [0051] 10 may be configured to carry spring clip 90 of FIGS. 4, or any of a variety of alternative expandable resilient clips. It is intended in the appended claims to cover all such changes and modifications that fall within the true spirit and scope of the invention.
    权利要求:
    Claims (24)
    [1" id="US-20010007077-A1-CLM-00001] 1. Apparatus for sealing a puncture in a vessel wall comprising:
    an introducer sheath having proximal and distal regions and an exterior surface;
    a housing coaxially and slidably disposed on the exterior surface of the introducer sheath, the housing including a portion defining a chamber;
    a clip resiliently expandable from an unstressed, deployed configuration wherein opposing sides of the clip are directed inwards towards one another, and an expanded, delivery configuration, in which the clip is slidably accepted within the chamber; and
    an actuator for deploying the clip from the chamber into engagement with the vessel wall to close the puncture.
    [2" id="US-20010007077-A1-CLM-00002] 2. The apparatus of
    claim 1 , wherein the actuator advances the clip from the proximal end of the sheath to the vessel wall.
    [3" id="US-20010007077-A1-CLM-00003] 3. The apparatus of
    claim 2 , wherein the actuator comprises at least one elongated member coupled to the housing.
    [4" id="US-20010007077-A1-CLM-00004] 4. The apparatus of
    claim 3 , wherein the at least one elongated member has a first position wherein the at least one elongated member engages the housing, and a second position wherein the at least one elongated member rotates the housing with respect to the expander to decrease an interior length of the chamber.
    [5" id="US-20010007077-A1-CLM-00005] 5. The apparatus of
    claim 1 , wherein the clip is fabricated from a superelastic material.
    [6" id="US-20010007077-A1-CLM-00006] 6. The apparatus of
    claim 1 , wherein the clip comprises a tubular member comprising a plurality of elongated tissue-engaging members.
    [7" id="US-20010007077-A1-CLM-00007] 7. The apparatus of
    claim 6 further comprising barbs attached to the tissue-engaging members.
    [8" id="US-20010007077-A1-CLM-00008] 8. The apparatus of
    claim 6 , wherein the tubular member further comprises a plurality of elongated legs having proximal and distal ends, a plurality of upper members connecting respective proximal ends of the elongated legs, and a plurality of lower members interconnecting respective alternating distal ends of the elongated legs, wherein the plurality of tissue-engaging members project from the plurality of lower members.
    [9" id="US-20010007077-A1-CLM-00009] 9. The apparatus of
    claim 1 , wherein the clip is bioabsorbable.
    [10" id="US-20010007077-A1-CLM-00010] 10. The apparatus of
    claim 1 further comprising at least one backbleed indicator port coupled to a proximal end of the introducer sheath to indicate a position of the housing relative to the puncture.
    [11" id="US-20010007077-A1-CLM-00011] 11. The apparatus of
    claim 10 wherein a tissue sealant may be delivered to the vessel wall in a vicinity of the puncture.
    [12" id="US-20010007077-A1-CLM-00012] 12. The apparatus of
    claim 1 further comprising a side port for introducing fluids into the introducer sheath.
    [13" id="US-20010007077-A1-CLM-00013] 13. A method of sealing a puncture in a vessel wall, the method comprising:
    providing apparatus comprising an introducer sheath having proximal and distal regions and a lumen extending therebetween, a housing slidably and coaxially disposed on the proximal region of the introducer sheath, a resilient clip disposed within the housing in an expanded delivery configuration, and a clip actuator;
    inserting the distal region of the introducer sheath through a patient's skin into a vessel via the puncture;
    performing an interventional or diagnostic procedure by advancing a device through the lumen of the introducer sheath;
    upon completion of the procedure, coupling the clip actuator to the housing;
    advancing the clip and housing through the skin with the clip actuator until the clip pierces the vessel wall on opposing sides of the puncture; and
    withdrawing the introducer sheath, housing, and clip actuator from the puncture so that the clip returns to an unstressed deployed configuration and seals the puncture.
    [14" id="US-20010007077-A1-CLM-00014] 14. The method of
    claim 13 further comprising delivering a tissue sealant to the vessel wall in a vicinity of the puncture.
    [15" id="US-20010007077-A1-CLM-00015] 15. The method of
    claim 13 wherein the housing further comprises backbleed indicator ports coupled to the proximal region of the introducer sheath, the method further comprising advancing the clip and housing until blood from the puncture flows through the backbleed indicator ports to the proximal region of the introducer sheath.
    [16" id="US-20010007077-A1-CLM-00016] 16. The method of
    claim 13 wherein the introducer further comprises a hub having a bore and the clip actuator further comprises an elongated member, wherein coupling the clip actuator to the housing further comprises inserting the elongated member through the bore of the hub.
    [17" id="US-20010007077-A1-CLM-00017] 17. The method of
    claim 13 wherein the apparatus further comprises an expander which expands the clip to the delivery configuration, and advancing the clip and housing further comprises advancing the housing relative to the expander to deploy the clip from within the housing.
    [18" id="US-20010007077-A1-CLM-00018] 18. Apparatus for sealing a vascular puncture comprising:
    an introducer sheath having proximal and distal regions, a lumen extending therebetween, and an exterior surface;
    an expander having an exterior surface, the expander slidably and coaxially disposed on the exterior surface of the introducer sheath;
    a housing coaxially disposed on and cammingly engaged with the expander, the housing including a portion defining a chamber;
    a resilient clip having an unstressed, deployed configuration, in which the clip closes the puncture, and an expanded, delivery configuration, in which the clip slidably passes over the exterior surface of the expander; and
    an actuator operably coupled to the housing for deploying the clip from the chamber.
    [19" id="US-20010007077-A1-CLM-00019] 19. The apparatus of
    claim 18 , wherein the actuator is fixedly coupled to the housing.
    [20" id="US-20010007077-A1-CLM-00020] 20. The apparatus of
    claim 18 , wherein the clip is fabricated from a superelastic material.
    [21" id="US-20010007077-A1-CLM-00021] 21. The apparatus of
    claim 18 , wherein the clip comprises a tubular member including a plurality of tissue-engaging members.
    [22" id="US-20010007077-A1-CLM-00022] 22. The apparatus of
    claim 18 , wherein the clip is bioabsorbable.
    [23" id="US-20010007077-A1-CLM-00023] 23. The apparatus of
    claim 18 further comprising at least on e backbleed indicator port coupled to a proximal end of the introducer sheath to indicate a position of the housing relative to the puncture.
    [24" id="US-20010007077-A1-CLM-00024] 24. The apparatus of
    claim 18 , wherein the actuator advances the clip from the proximal end of the sheath to the puncture.
    类似技术:
    公开号 | 公开日 | 专利标题
    US6197042B1|2001-03-06|Vascular sheath with puncture site closure apparatus and methods of use
    US7901428B2|2011-03-08|Vascular sheath with bioabsorbable puncture site closure apparatus and methods of use
    EP1593347B1|2007-09-05|Apparatus for closing an opening in tissue
    US7931669B2|2011-04-26|Integrated vascular device with puncture site closure component and sealant and methods of use
    US8597325B2|2013-12-03|Apparatus and methods for providing tactile feedback while delivering a closure device
    AU2002232508B2|2006-07-13|Apparatus for delivering a closure device to an opening of a body lumen
    US7144411B2|2006-12-05|Apparatus and methods for positioning a vascular sheath
    同族专利:
    公开号 | 公开日
    US6197042B1|2001-03-06|
    US20060190014A1|2006-08-24|
    US20060190037A1|2006-08-24|
    US6632238B2|2003-10-14|
    US6277140B2|2001-08-21|
    US20020002386A1|2002-01-03|
    引用文献:
    公开号 | 申请日 | 公开日 | 申请人 | 专利标题
    US20030109890A1|2000-09-01|2003-06-12|Glenn Kanner|Advanced wound site management systems and methods|
    US20030199924A1|2000-09-08|2003-10-23|James Coleman|Surgical stapler|
    US7074232B2|2000-09-01|2006-07-11|Medtronic Angiolink, Inc.|Advanced wound site management systems and methods|
    US20060217744A1|2005-03-28|2006-09-28|Cardica, Inc.|Vascular closure system|
    US20060282104A1|2004-05-13|2006-12-14|Cleveland Clinic Foundation|Skin lesion exciser and skin-closure device therefor|
    US20080071294A1|2006-09-15|2008-03-20|Bender Theodore M|Apparatus and method for closure of patent foramen ovale|
    US20080217376A1|2007-03-08|2008-09-11|Cardica, Inc.|Surgical Stapler|
    US7458978B1|2005-03-28|2008-12-02|Cardica, Inc.|Vascular closure system utilizing a staple|
    US20090093826A1|2007-10-05|2009-04-09|Cardica, Inc.|Patent Foramen Ovale Closure System|
    US7533790B1|2007-03-08|2009-05-19|Cardica, Inc.|Surgical stapler|
    US20090254121A1|2008-04-02|2009-10-08|Cardica, Inc.|Vascular Closure with Multi-Pronged Clip|
    USD611144S1|2006-06-28|2010-03-02|Abbott Laboratories|Apparatus for delivering a closure element|
    US7806904B2|2000-12-07|2010-10-05|Integrated Vascular Systems, Inc.|Closure device|
    US7806910B2|2002-11-26|2010-10-05|Abbott Laboratories|Multi-element biased suture clip|
    US7819895B2|2000-01-05|2010-10-26|Integrated Vascular Systems, Inc.|Vascular sheath with bioabsorbable puncture site closure apparatus and methods of use|
    US7828817B2|2000-01-05|2010-11-09|Integrated Vascular Systems, Inc.|Apparatus and methods for delivering a closure device|
    US7842068B2|2000-12-07|2010-11-30|Integrated Vascular Systems, Inc.|Apparatus and methods for providing tactile feedback while delivering a closure device|
    US7841502B2|2007-12-18|2010-11-30|Abbott Laboratories|Modular clip applier|
    US7850797B2|2002-12-31|2010-12-14|Integrated Vascular Systems, Inc.|Methods for manufacturing a clip and clip|
    US7850709B2|2002-06-04|2010-12-14|Abbott Vascular Inc.|Blood vessel closure clip and delivery device|
    US7867249B2|2003-01-30|2011-01-11|Integrated Vascular Systems, Inc.|Clip applier and methods of use|
    US7879071B2|2000-12-07|2011-02-01|Integrated Vascular Systems, Inc.|Closure device and methods for making and using them|
    US7887563B2|2001-06-07|2011-02-15|Abbott Vascular Inc.|Surgical staple|
    US7931669B2|2000-01-05|2011-04-26|Integrated Vascular Systems, Inc.|Integrated vascular device with puncture site closure component and sealant and methods of use|
    US8007512B2|2002-02-21|2011-08-30|Integrated Vascular Systems, Inc.|Plunger apparatus and methods for delivering a closure device|
    US8202293B2|2003-01-30|2012-06-19|Integrated Vascular Systems, Inc.|Clip applier and methods of use|
    US8202294B2|2003-01-30|2012-06-19|Integrated Vascular Systems, Inc.|Clip applier and methods of use|
    US8226681B2|2007-06-25|2012-07-24|Abbott Laboratories|Methods, devices, and apparatus for managing access through tissue|
    US8303624B2|2010-03-15|2012-11-06|Abbott Cardiovascular Systems, Inc.|Bioabsorbable plug|
    US8313497B2|2005-07-01|2012-11-20|Abbott Laboratories|Clip applier and methods of use|
    US8323312B2|2008-12-22|2012-12-04|Abbott Laboratories|Closure device|
    US8398656B2|2003-01-30|2013-03-19|Integrated Vascular Systems, Inc.|Clip applier and methods of use|
    US8398676B2|2008-10-30|2013-03-19|Abbott Vascular Inc.|Closure device|
    US8518063B2|2001-04-24|2013-08-27|Russell A. Houser|Arteriotomy closure devices and techniques|
    US8556932B2|2011-05-19|2013-10-15|Abbott Cardiovascular Systems, Inc.|Collapsible plug for tissue closure|
    US8556930B2|2006-06-28|2013-10-15|Abbott Laboratories|Vessel closure device|
    US8590760B2|2004-05-25|2013-11-26|Abbott Vascular Inc.|Surgical stapler|
    US8603116B2|2010-08-04|2013-12-10|Abbott Cardiovascular Systems, Inc.|Closure device with long tines|
    US8617184B2|2011-02-15|2013-12-31|Abbott Cardiovascular Systems, Inc.|Vessel closure system|
    US8672953B2|2007-12-17|2014-03-18|Abbott Laboratories|Tissue closure system and methods of use|
    US8690910B2|2000-12-07|2014-04-08|Integrated Vascular Systems, Inc.|Closure device and methods for making and using them|
    US8758399B2|2010-08-02|2014-06-24|Abbott Cardiovascular Systems, Inc.|Expandable bioabsorbable plug apparatus and method|
    US8758398B2|2006-09-08|2014-06-24|Integrated Vascular Systems, Inc.|Apparatus and method for delivering a closure element|
    US8758400B2|2000-01-05|2014-06-24|Integrated Vascular Systems, Inc.|Closure system and methods of use|
    US8808310B2|2006-04-20|2014-08-19|Integrated Vascular Systems, Inc.|Resettable clip applier and reset tools|
    US8821534B2|2010-12-06|2014-09-02|Integrated Vascular Systems, Inc.|Clip applier having improved hemostasis and methods of use|
    US8858594B2|2008-12-22|2014-10-14|Abbott Laboratories|Curved closure device|
    US8893947B2|2007-12-17|2014-11-25|Abbott Laboratories|Clip applier and methods of use|
    US8905937B2|2009-02-26|2014-12-09|Integrated Vascular Systems, Inc.|Methods and apparatus for locating a surface of a body lumen|
    US8920442B2|2005-08-24|2014-12-30|Abbott Vascular Inc.|Vascular opening edge eversion methods and apparatuses|
    US8926633B2|2005-06-24|2015-01-06|Abbott Laboratories|Apparatus and method for delivering a closure element|
    US8961541B2|2007-12-03|2015-02-24|Cardio Vascular Technologies Inc.|Vascular closure devices, systems, and methods of use|
    US8992567B1|2001-04-24|2015-03-31|Cardiovascular Technologies Inc.|Compressible, deformable, or deflectable tissue closure devices and method of manufacture|
    US9089311B2|2009-01-09|2015-07-28|Abbott Vascular Inc.|Vessel closure devices and methods|
    US9089674B2|2000-10-06|2015-07-28|Integrated Vascular Systems, Inc.|Apparatus and methods for positioning a vascular sheath|
    US9131931B2|2013-01-21|2015-09-15|Vi Bravoseal, Llc|Vessel sealing device with automatic deployment|
    US9138215B2|2013-01-21|2015-09-22|Vi Bravoseal, Llc|Vessel sealing device|
    US9149276B2|2011-03-21|2015-10-06|Abbott Cardiovascular Systems, Inc.|Clip and deployment apparatus for tissue closure|
    US9173644B2|2009-01-09|2015-11-03|Abbott Vascular Inc.|Closure devices, systems, and methods|
    US9282965B2|2008-05-16|2016-03-15|Abbott Laboratories|Apparatus and methods for engaging tissue|
    US9314230B2|2009-01-09|2016-04-19|Abbott Vascular Inc.|Closure device with rapidly eroding anchor|
    US9332976B2|2011-11-30|2016-05-10|Abbott Cardiovascular Systems, Inc.|Tissue closure device|
    US9345460B2|2001-04-24|2016-05-24|Cardiovascular Technologies, Inc.|Tissue closure devices, device and systems for delivery, kits and methods therefor|
    US9364209B2|2012-12-21|2016-06-14|Abbott Cardiovascular Systems, Inc.|Articulating suturing device|
    US9414824B2|2009-01-16|2016-08-16|Abbott Vascular Inc.|Closure devices, systems, and methods|
    US9414820B2|2009-01-09|2016-08-16|Abbott Vascular Inc.|Closure devices, systems, and methods|
    US9456811B2|2005-08-24|2016-10-04|Abbott Vascular Inc.|Vascular closure methods and apparatuses|
    US9486191B2|2009-01-09|2016-11-08|Abbott Vascular, Inc.|Closure devices|
    US9579091B2|2000-01-05|2017-02-28|Integrated Vascular Systems, Inc.|Closure system and methods of use|
    US9585647B2|2009-08-26|2017-03-07|Abbott Laboratories|Medical device for repairing a fistula|
    US10307145B2|2013-01-21|2019-06-04|Cyndrx, Llc|Vessel sealing device|US1088393A|1913-09-20|1914-02-24|Oscar E Backus|Button.|
    US1331401A|1919-09-12|1920-02-17|Summers Henry Clay|Button-fastening|
    US2316297A|1943-01-15|1943-04-13|Beverly A Southerland|Surgical instrument|
    US2583625A|1946-10-29|1952-01-29|Thomas & Betts Corp|Method of and tool for crimping tubes|
    US2969887A|1959-04-08|1961-01-31|American Thermos Products Comp|Threaded pouring lip stopper combination for vacuum bottle|
    US3015403A|1959-04-08|1962-01-02|American Thermos Products Comp|Threaded stopper expanding pouring lip combination for vacuum bottle|
    US3120230A|1960-10-24|1964-02-04|Jack H Sanders|Surgical clamp|
    US3523351A|1967-10-20|1970-08-11|Sargent & Co|Locator and holder in a crimping tool for an electrical connector|
    US3586002A|1968-01-08|1971-06-22|Ernest C Wood|Surgical skin clip|
    US3604425A|1969-04-11|1971-09-14|New Research And Dev Lab Inc|Hemostatic clip|
    US3757629A|1971-05-10|1973-09-11|R Schneider|Resilient plastic staple|
    BE789131A|1971-09-24|1973-03-22|Extracorporeal Med Spec|SURGICAL NEEDLE FOR PERFORMING MEDICAL OPERATIONS|
    US3828791A|1973-03-21|1974-08-13|M Santos|Surgical instruments|
    US3805337A|1973-04-23|1974-04-23|Raymond Lee Organization Inc|Spring wire hose clamp|
    NL7403762A|1974-03-20|1975-09-23|Leer Koninklijke Emballage|STOP OF PLASTIC OR SIMILAR MATERIAL, WITH EXTERNAL THREADS.|
    US4014492A|1975-06-11|1977-03-29|Senco Products, Inc.|Surgical staple|
    DE2658478C2|1976-12-23|1978-11-30|Aesculap-Werke Ag Vormals Jetter & Scheerer, 7200 Tuttlingen|Vascular clips for surgical use|
    US4217902A|1977-05-02|1980-08-19|March Alfred L|Hemostatic clip|
    US4201215A|1977-09-06|1980-05-06|Crossett E S|Apparatus and method for closing a severed sternum|
    US4345606A|1977-12-13|1982-08-24|Littleford Philip O|Split sleeve introducers for pacemaker electrodes and the like|
    US4207870A|1978-06-15|1980-06-17|Becton, Dickinson And Company|Blood sampling assembly having porous vent means vein entry indicator|
    USRE31855F1|1978-12-01|1986-08-19||Tear apart cannula|
    US4440170A|1979-03-06|1984-04-03|Ethicon, Inc.|Surgical clip applying instrument|
    US4396139A|1980-02-15|1983-08-02|Technalytics, Inc.|Surgical stapling system, apparatus and staple|
    US4318401A|1980-04-24|1982-03-09|President And Fellows Of Harvard College|Percutaneous vascular access portal and catheter|
    US4428376A|1980-05-02|1984-01-31|Ethicon Inc.|Plastic surgical staple|
    US4327485A|1980-05-21|1982-05-04|Amp Incorporated|Pistol grip tool|
    US4505274A|1980-10-17|1985-03-19|Propper Manufacturing Co., Inc.|Suture clip|
    US4485816A|1981-06-25|1984-12-04|Alchemia|Shape-memory surgical staple apparatus and method for use in surgical suturing|
    US4724840A|1982-02-03|1988-02-16|Ethicon, Inc.|Surgical fastener applier with rotatable front housing and laterally extending curved needle for guiding a flexible pusher|
    DE3204532C2|1982-02-10|1983-12-08|B. Braun Melsungen Ag, 3508 Melsungen|Surgical skin staple|
    DE3204522C2|1982-02-10|1988-08-25|B. Braun Melsungen Ag, 3508 Melsungen, De||
    US4860746A|1982-04-20|1989-08-29|Inbae Yoon|Elastic surgical ring clip and ring loader|
    US4492232A|1982-09-30|1985-01-08|United States Surgical Corporation|Surgical clip applying apparatus having fixed jaws|
    US4510251A|1982-11-08|1985-04-09|Abbott Laboratories|Fluorescent polarization assay for ligands using aminomethylfluorescein derivatives as tracers|
    US4525157A|1983-07-28|1985-06-25|Manresa, Inc.|Closed system catheter with guide wire|
    US4665906A|1983-10-14|1987-05-19|Raychem Corporation|Medical devices incorporating sim alloy elements|
    US4510252A|1983-11-18|1985-04-09|Owens-Corning Fiberglas Corporation|Easily formed chemically resistant glass fibers|
    US4586503A|1983-12-01|1986-05-06|University Of New Mexico|Surgical microclip|
    US4917087A|1984-04-10|1990-04-17|Walsh Manufacturing Limited|Anastomosis devices, kits and method|
    DE3420455C1|1984-06-01|1985-05-15|Peter Dr.-Ing. 7889 Grenzach-Wyhlen Osypka|Separating device for an insertion sleeve|
    US4635635A|1984-11-29|1987-01-13|Aspen Laboratories, Inc.|Tourniquet cuff|
    US4635634A|1985-07-12|1987-01-13|Santos Manuel V|Surgical clip applicator system|
    DE3533423C2|1985-09-19|1990-02-22|Richard Wolf Gmbh, 7134 Knittlingen, De||
    JPH0522551B2|1986-04-09|1993-03-29|Terumo Corp||
    US4777950A|1986-04-11|1988-10-18|Kees Surgical Specialty Co.|Vascular clip|
    US4738658A|1986-09-19|1988-04-19|Aries Medical Incorporated|Tapered hemostatic device for use in conjunction with a catheter for alleviating blood leakage and method for using same|
    US4744364A|1987-02-17|1988-05-17|Intravascular Surgical Instruments, Inc.|Device for sealing percutaneous puncture in a vessel|
    USRE34866E|1987-02-17|1995-02-21|Kensey Nash Corporation|Device for sealing percutaneous puncture in a vessel|
    US4865026A|1987-04-23|1989-09-12|Barrett David M|Sealing wound closure device|
    US5100418A|1987-05-14|1992-03-31|Inbae Yoon|Suture tie device system and applicator therefor|
    US4836204A|1987-07-06|1989-06-06|Landymore Roderick W|Method for effecting closure of a perforation in the septum of the heart|
    JP2561853B2|1988-01-28|1996-12-11|株式会社ジェイ・エム・エス|Shaped memory molded article and method of using the same|
    US5015247A|1988-06-13|1991-05-14|Michelson Gary K|Threaded spinal implant|
    FR2641692B1|1989-01-17|1995-05-12|Nippon Zeon Co||
    US5026390A|1989-10-26|1991-06-25|Brown Alan W|Surgical staple|
    US5007921A|1989-10-26|1991-04-16|Brown Alan W|Surgical staple|
    GB8924806D0|1989-11-03|1989-12-20|Neoligaments Ltd|Prosthectic ligament system|
    US5061274A|1989-12-04|1991-10-29|Kensey Nash Corporation|Plug device for sealing openings and method of use|
    CA2122041A1|1989-12-04|1993-04-29|Kenneth Kensey|Plug device for sealing openings and method of use|
    US5156609A|1989-12-26|1992-10-20|Nakao Naomi L|Endoscopic stapling device and method|
    US5032127A|1990-03-07|1991-07-16|Frazee John G|Hemostatic clip and applicator therefor|
    US5021059A|1990-05-07|1991-06-04|Kensey Nash Corporation|Plug device with pulley for sealing punctures in tissue and methods of use|
    US5116349A|1990-05-23|1992-05-26|United States Surgical Corporation|Surgical fastener apparatus|
    US5078731A|1990-06-05|1992-01-07|Hayhurst John O|Suture clip|
    US5192300A|1990-10-01|1993-03-09|Quinton Instrument Company|Insertion assembly and method of inserting a vessel plug into the body of a patient|
    US5108421A|1990-10-01|1992-04-28|Quinton Instrument Company|Insertion assembly and method of inserting a vessel plug into the body of a patient|
    CA2027427A1|1990-10-12|1992-04-13|William S. Laidlaw|Plug for sealing wood preservative in wood structures|
    US5053008A|1990-11-21|1991-10-01|Sandeep Bajaj|Intracardiac catheter|
    US5366458A|1990-12-13|1994-11-22|United States Surgical Corporation|Latchless surgical clip|
    US5425489A|1990-12-20|1995-06-20|United States Surgical Corporation|Fascia clip and instrument|
    US5108420A|1991-02-01|1992-04-28|Temple University|Aperture occlusion device|
    CA2060040A1|1991-02-08|1992-08-10|Miguel A. Velez|Surgical staple and endoscopic stapler|
    US5290310A|1991-10-30|1994-03-01|Howmedica, Inc.|Hemostatic implant introducer|
    US5282827A|1991-11-08|1994-02-01|Kensey Nash Corporation|Hemostatic puncture closure system and method of use|
    US5411520A|1991-11-08|1995-05-02|Kensey Nash Corporation|Hemostatic vessel puncture closure system utilizing a plug located within the puncture tract spaced from the vessel, and method of use|
    US5222974A|1991-11-08|1993-06-29|Kensey Nash Corporation|Hemostatic puncture closure system and method of use|
    US5176648A|1991-12-13|1993-01-05|Unisurge, Inc.|Introducer assembly and instrument for use therewith|
    US6056768A|1992-01-07|2000-05-02|Cates; Christopher U.|Blood vessel sealing system|
    DE4200255A1|1992-01-08|1993-07-15|Sueddeutsche Feinmechanik|SPLIT CANNULA AND METHOD FOR PRODUCING SUCH A|
    JP3393383B2|1992-01-21|2003-04-07|リージェンツオブザユニバーシティオブミネソタ|Septal defect closure device|
    CA2090980C|1992-03-06|2004-11-30|David Stefanchik|Ligating clip applier|
    WO1993020768A1|1992-04-13|1993-10-28|Ep Technologies, Inc.|Steerable microwave antenna systems for cardiac ablation|
    US6063085A|1992-04-23|2000-05-16|Scimed Life Systems, Inc.|Apparatus and method for sealing vascular punctures|
    DE4215449C1|1992-05-11|1993-09-02|Ethicon Gmbh & Co Kg, 2000 Norderstedt, De||
    US5431667A|1992-05-26|1995-07-11|Origin Medsystems, Inc.|Gas-sealed instruments for use in laparoscopic surgery|
    US5192288A|1992-05-26|1993-03-09|Origin Medsystems, Inc.|Surgical clip applier|
    JPH0647050A|1992-06-04|1994-02-22|Olympus Optical Co Ltd|Tissue suture and ligature device|
    US5290243A|1992-07-16|1994-03-01|Technalytics, Inc.|Trocar system|
    US5413571A|1992-07-16|1995-05-09|Sherwood Medical Company|Device for sealing hemostatic incisions|
    US5292332A|1992-07-27|1994-03-08|Lee Benjamin I|Methods and device for percutanceous sealing of arterial puncture sites|
    US5306254A|1992-10-01|1994-04-26|Kensey Nash Corporation|Vessel position locating device and method of use|
    US5304184A|1992-10-19|1994-04-19|Indiana University Foundation|Apparatus and method for positive closure of an internal tissue membrane opening|
    CZ281454B6|1992-11-23|1996-10-16|Milan Mudr. Csc. Krajíček|Aid for non-surgical closing of a hole in a vessel wall|
    US5417699A|1992-12-10|1995-05-23|Perclose Incorporated|Device and method for the percutaneous suturing of a vascular puncture site|
    US5292309A|1993-01-22|1994-03-08|Schneider Inc.|Surgical depth measuring instrument and method|
    US5320639A|1993-03-12|1994-06-14|Meadox Medicals, Inc.|Vascular plug delivery system|
    US5478354A|1993-07-14|1995-12-26|United States Surgical Corporation|Wound closing apparatus and method|
    US5507755A|1993-08-03|1996-04-16|Origin Medsystems, Inc.|Apparatus and method for closing puncture wounds|
    US5830125A|1993-08-12|1998-11-03|Scribner-Browne Medical Design Incorporated|Catheter introducer with suture capability|
    US5725554A|1993-10-08|1998-03-10|Richard-Allan Medical Industries, Inc.|Surgical staple and stapler|
    US5423857A|1993-11-02|1995-06-13|Ethicon, Inc.|Three piece surgical staple|
    US5527322A|1993-11-08|1996-06-18|Perclose, Inc.|Device and method for suturing of internal puncture sites|
    US5728122A|1994-01-18|1998-03-17|Datascope Investment Corp.|Guide wire with releaseable barb anchor|
    US5416584A|1994-04-25|1995-05-16|Honeywell Inc.|Sinusoidal noise injection into the dither of a ring laser gyroscope|
    US5478309A|1994-05-27|1995-12-26|William P. Sweezer, Jr.|Catheter system and method for providing cardiopulmonary bypass pump support during heart surgery|
    US5732872A|1994-06-17|1998-03-31|Heartport, Inc.|Surgical stapling instrument|
    US5549633A|1994-08-24|1996-08-27|Kensey Nash Corporation|Apparatus and methods of use for preventing blood seepage at a percutaneous puncture site|
    US5620452A|1994-12-22|1997-04-15|Yoon; Inbae|Surgical clip with ductile tissue penetrating members|
    US5904697A|1995-02-24|1999-05-18|Heartport, Inc.|Devices and methods for performing a vascular anastomosis|
    US5695505A|1995-03-09|1997-12-09|Yoon; Inbae|Multifunctional spring clips and cartridges and applicators therefor|
    US5634911A|1995-05-19|1997-06-03|General Surgical Innovations, Inc.|Screw-type skin seal with inflatable membrane|
    US5810846A|1995-08-03|1998-09-22|United States Surgical Corporation|Vascular hole closure|
    US5683405A|1995-08-25|1997-11-04|Research Medical Inc.|Vascular occluder|
    US5674231A|1995-10-20|1997-10-07|United States Surgical Corporation|Apparatus and method for vascular hole closure|
    US6425901B1|1995-12-07|2002-07-30|Loma Linda University Medical Center|Vascular wound closure system|
    WO1997020505A1|1995-12-07|1997-06-12|Loma Linda University Medical Center|Vascular wound closure device|
    US5810851A|1996-03-05|1998-09-22|Yoon; Inbae|Suture spring device|
    US5782844A|1996-03-05|1998-07-21|Inbae Yoon|Suture spring device applicator|
    US5728132A|1996-04-08|1998-03-17|Tricardia, L.L.C.|Self-sealing vascular access device|
    US5855312A|1996-07-25|1999-01-05|Toledano; Haviv|Flexible annular stapler for closed surgery of hollow organs|
    US5902310A|1996-08-12|1999-05-11|Ethicon Endo-Surgery, Inc.|Apparatus and method for marking tissue|
    GB2318295A|1996-10-17|1998-04-22|Malachy Gleeson|Wire-guided surgical stapler for closure of a puncture site in a blood vessel|
    US5879366A|1996-12-20|1999-03-09|W.L. Gore & Associates, Inc.|Self-expanding defect closure device and method of making and using|
    US5782861A|1996-12-23|1998-07-21|Sub Q Inc.|Percutaneous hemostasis device|
    US5861005A|1997-02-11|1999-01-19|X-Site, L.L.C.|Arterial stapling device|
    US5782860A|1997-02-11|1998-07-21|Biointerventional Corporation|Closure device for percutaneous occlusion of puncture sites and tracts in the human body and method|
    US6045570A|1997-02-11|2000-04-04|Biointerventional Corporation|Biological sealant mixture and system for use in percutaneous occlusion of puncture sites and tracts in the human body and method|
    US6056770A|1997-02-11|2000-05-02|Biointerventional Corporation|Expansile device for use in blood vessels and tracts in the body and method|
    US6056769A|1997-02-11|2000-05-02|Biointerventional Corporation|Expansile device for use in blood vessels and tracts in the body and tension application device for use therewith and method|
    US6409739B1|1997-05-19|2002-06-25|Cardio Medical Solutions, Inc.|Device and method for assisting end-to side anastomosis|
    US6030364A|1997-10-03|2000-02-29|Boston Scientific Corporation|Apparatus and method for percutaneous placement of gastro-intestinal tubes|
    US5984934A|1997-10-10|1999-11-16|Applied Medical Resources Corporation|Low-profile surgical clip|
    US6036720A|1997-12-15|2000-03-14|Target Therapeutics, Inc.|Sheet metal aneurysm neck bridge|
    US7396359B1|1998-05-29|2008-07-08|Bypass, Inc.|Vascular port device|
    WO2000056227A1|1999-03-19|2000-09-28|By-Pass, Inc.|Advanced closure device|
    WO2000056226A1|1999-03-19|2000-09-28|By-Pass, Inc.|Vascular surgery|
    US6726704B1|1998-05-29|2004-04-27|By-Pass, Inc.|Advanced closure device|
    US5910155A|1998-06-05|1999-06-08|United States Surgical Corporation|Vascular wound closure system|
    US6048358A|1998-07-13|2000-04-11|Barak; Shlomo|Method and apparatus for hemostasis following arterial catheterization|
    IL141014D0|1998-07-22|2002-02-10|Angiolink Corp|Vascular suction cannula, dilator and surgical stapler|
    AU5247799A|1998-08-04|2000-02-28|Fusion Medical Technologies, Inc.|Percutaneous tissue track closure assembly and method|
    US6334865B1|1998-08-04|2002-01-01|Fusion Medical Technologies, Inc.|Percutaneous tissue track closure assembly and method|
    US6080183A|1998-11-24|2000-06-27|Embol-X, Inc.|Sutureless vessel plug and methods of use|
    US6110184A|1999-08-04|2000-08-29|Weadock; Kevin S.|Introducer with vascular sealing mechanism|
    US7341595B2|1999-09-13|2008-03-11|Rex Medical, L.P|Vascular hole closure device|
    CA2381818C|1999-09-13|2009-08-04|Rex Medical, L.P.|Vascular closure|
    US6780197B2|2000-01-05|2004-08-24|Integrated Vascular Systems, Inc.|Apparatus and methods for delivering a vascular closure device to a body lumen|
    US6197042B1|2000-01-05|2001-03-06|Medical Technology Group, Inc.|Vascular sheath with puncture site closure apparatus and methods of use|
    US7842068B2|2000-12-07|2010-11-30|Integrated Vascular Systems, Inc.|Apparatus and methods for providing tactile feedback while delivering a closure device|
    US6391048B1|2000-01-05|2002-05-21|Integrated Vascular Systems, Inc.|Integrated vascular device with puncture site closure component and sealant and methods of use|
    US6461364B1|2000-01-05|2002-10-08|Integrated Vascular Systems, Inc.|Vascular sheath with bioabsorbable puncture site closure apparatus and methods of use|
    US6547806B1|2000-02-04|2003-04-15|Ni Ding|Vascular sealing device and method of use|
    US6767356B2|2000-09-01|2004-07-27|Angiolink Corporation|Advanced wound site management systems and methods|
    US6533762B2|2000-09-01|2003-03-18|Angiolink Corporation|Advanced wound site management systems and methods|
    US6506210B1|2000-09-01|2003-01-14|Angiolink Corporation|Wound site management and wound closure device|
    AT485006T|2000-09-08|2010-11-15|Abbott Vascular Inc|DEVICE FOR LOCATING A POINTED BLOOD VESSEL|
    US7806904B2|2000-12-07|2010-10-05|Integrated Vascular Systems, Inc.|Closure device|
    US7211101B2|2000-12-07|2007-05-01|Abbott Vascular Devices|Methods for manufacturing a clip and clip|
    US6623510B2|2000-12-07|2003-09-23|Integrated Vascular Systems, Inc.|Closure device and methods for making and using them|
    US6719777B2|2000-12-07|2004-04-13|Integrated Vascular Systems, Inc.|Closure device and methods for making and using them|
    US6846319B2|2000-12-14|2005-01-25|Core Medical, Inc.|Devices for sealing openings through tissue and apparatus and methods for delivering them|
    IES20010547A2|2001-06-07|2002-12-11|Christy Cummins|Surgical Staple|
    IES20010749A2|2001-08-09|2003-02-19|Christy Cummins|Surgical Stapling Device|
    IES20010748A2|2001-08-09|2003-02-19|Christy Cummins|Surgical Stapling Device and Method|
    US6695867B2|2002-02-21|2004-02-24|Integrated Vascular Systems, Inc.|Plunger apparatus and methods for delivering a closure device|
    US7857828B2|2003-01-30|2010-12-28|Integrated Vascular Systems, Inc.|Clip applier and methods of use|
    US7513537B2|2003-10-22|2009-04-07|Frank's Casing Crew & Rental Tools, Inc.|Tubular connection with slotted threads|
    US7326230B2|2003-10-23|2008-02-05|Sundaram Ravikumar|Vascular sealing device and method of use|US20020095164A1|1997-06-26|2002-07-18|Andreas Bernard H.|Device and method for suturing tissue|
    US7029480B2|2001-01-24|2006-04-18|Abott Laboratories|Device and method for suturing of internal puncture sites|
    US6287322B1|1995-12-07|2001-09-11|Loma Linda University Medical Center|Tissue opening locator and everter and method|
    US20020019642A1|1996-07-23|2002-02-14|Keith Milliman|Anastomosis instrument and method for performing same|
    US7223273B2|1996-07-23|2007-05-29|Tyco Healthcare Group Lp|Anastomosis instrument and method for performing same|
    US6440146B2|1996-07-23|2002-08-27|United States Surgical Corporation|Anastomosis instrument and method|
    US7396359B1|1998-05-29|2008-07-08|Bypass, Inc.|Vascular port device|
    US6726704B1|1998-05-29|2004-04-27|By-Pass, Inc.|Advanced closure device|
    US20050283188A1|1998-05-29|2005-12-22|By-Pass, Inc.|Vascular closure device|
    DK1051116T3|1998-12-01|2009-02-02|Univ Washington|Embolization device|
    US6964668B2|1999-03-04|2005-11-15|Abbott Laboratories|Articulating suturing device and method|
    US7001400B1|1999-03-04|2006-02-21|Abbott Laboratories|Articulating suturing device and method|
    US7235087B2|1999-03-04|2007-06-26|Abbott Park|Articulating suturing device and method|
    US20040092964A1|1999-03-04|2004-05-13|Modesitt D. Bruce|Articulating suturing device and method|
    CA2381818C|1999-09-13|2009-08-04|Rex Medical, L.P.|Vascular closure|
    US7267679B2|1999-09-13|2007-09-11|Rex Medical, L.P|Vascular hole closure device|
    US8083766B2|1999-09-13|2011-12-27|Rex Medical, Lp|Septal defect closure device|
    US7942888B2|1999-09-13|2011-05-17|Rex Medical, L.P.|Vascular hole closure device|
    US7662161B2|1999-09-13|2010-02-16|Rex Medical, L.P|Vascular hole closure device|
    US7341595B2|1999-09-13|2008-03-11|Rex Medical, L.P|Vascular hole closure device|
    US6475189B1|1999-12-21|2002-11-05|Ethicon, Inc.|Apparatus and method for a self-blunting safety catheter|
    US6780197B2|2000-01-05|2004-08-24|Integrated Vascular Systems, Inc.|Apparatus and methods for delivering a vascular closure device to a body lumen|
    US6197042B1|2000-01-05|2001-03-06|Medical Technology Group, Inc.|Vascular sheath with puncture site closure apparatus and methods of use|
    DE60127236T2|2000-01-18|2007-11-22|Tyco Healthcare Group Lp, Norwalk|Instrument for anastomosis|
    US8088060B2|2000-03-15|2012-01-03|Orbusneich Medical, Inc.|Progenitor endothelial cell capturing with a drug eluting implantable medical device|
    US9522217B2|2000-03-15|2016-12-20|Orbusneich Medical, Inc.|Medical device with coating for capturing genetically-altered cells and methods for using same|
    US6440152B1|2000-07-28|2002-08-27|Microvena Corporation|Defect occluder release assembly and method|
    US6890342B2|2000-08-02|2005-05-10|Loma Linda University|Method and apparatus for closing vascular puncture using hemostatic material|
    US8551134B2|2000-09-01|2013-10-08|Medtronic Vascular, Inc.|Wound site management and wound closure device|
    US6755842B2|2000-09-01|2004-06-29|Angiolink Corporation|Advanced wound site management systems and methods|
    US6767356B2|2000-09-01|2004-07-27|Angiolink Corporation|Advanced wound site management systems and methods|
    US20040093024A1|2000-09-01|2004-05-13|James Lousararian|Advanced wound site management systems and methods|
    US7241302B2|2001-10-18|2007-07-10|Tyco Healthcare Group Lp|Anastomosis instrument and method for performing same|
    US6719777B2|2000-12-07|2004-04-13|Integrated Vascular Systems, Inc.|Closure device and methods for making and using them|
    US6846319B2|2000-12-14|2005-01-25|Core Medical, Inc.|Devices for sealing openings through tissue and apparatus and methods for delivering them|
    US8083768B2|2000-12-14|2011-12-27|Ensure Medical, Inc.|Vascular plug having composite construction|
    US6623509B2|2000-12-14|2003-09-23|Core Medical, Inc.|Apparatus and methods for sealing vascular punctures|
    US6890343B2|2000-12-14|2005-05-10|Ensure Medical, Inc.|Plug with detachable guidewire element and methods for use|
    US6896692B2|2000-12-14|2005-05-24|Ensure Medical, Inc.|Plug with collet and apparatus and method for delivering such plugs|
    US20020099410A1|2001-01-11|2002-07-25|Bio-Seal Tech Inc.|Device and method for sealing a puncture in a blood vessel|
    US6632237B2|2001-01-11|2003-10-14|Bio-Seal Tech, Inc.|Device and method for sealing a puncture in a blood vessel|
    JP4130584B2|2001-01-24|2008-08-06|タイコヘルスケアグループリミテッドパートナーシップ|Anastomosis instrument and method for performing anastomosis|
    US7025776B1|2001-04-24|2006-04-11|Advanced Catheter Engineering, Inc.|Arteriotomy closure devices and techniques|
    EP1408847B1|2001-07-26|2005-05-04|Oregon Health Sciences University|Vessel closure member and delivery apparatus|
    US8465516B2|2001-07-26|2013-06-18|Oregon Health Science University|Bodily lumen closure apparatus and method|
    US7288105B2|2001-08-01|2007-10-30|Ev3 Endovascular, Inc.|Tissue opening occluder|
    IES20010748A2|2001-08-09|2003-02-19|Christy Cummins|Surgical Stapling Device and Method|
    IES20010749A2|2001-08-09|2003-02-19|Christy Cummins|Surgical Stapling Device|
    US8409167B2|2004-07-19|2013-04-02|Broncus Medical Inc|Devices for delivering substances through an extra-anatomic opening created in an airway|
    US20060025788A1|2002-09-25|2006-02-02|By-Pass, Inc.|Anastomotic leg arrangement|
    US7094245B2|2001-10-05|2006-08-22|Scimed Life Systems, Inc.|Device and method for through the scope endoscopic hemostatic clipping|
    US8012165B2|2001-10-22|2011-09-06|Interventional Therapies|Removable sleeve|
    AU2003231752A1|2002-04-22|2003-11-03|Tyco Healthcare Group, Lp|Tack and tack applier|
    US7153286B2|2002-05-24|2006-12-26|Baxter International Inc.|Automated dialysis system|
    US7195142B2|2003-05-30|2007-03-27|Tyco Healthcare Group Lp|End-to-end anastomosis instrument and method for performing same|
    US6769594B2|2002-05-31|2004-08-03|Tyco Healthcare Group, Lp|End-to-end anastomosis instrument and method for performing same|
    CA2488751C|2002-06-14|2012-04-17|Loma Linda University Medical Center|Vascular wound closure device and method|
    IES20030490A2|2002-07-03|2004-01-14|Paul Hooi|Surgical stapling device|
    WO2004023976A2|2002-09-13|2004-03-25|Damage Control Surgical Technologies, Inc.|Method and apparatus for vascular and visceral clipping|
    WO2004054156A2|2002-12-06|2004-06-24|Fast Country, Inc.|Systems and methods for providing interactive guest resources|
    US7160309B2|2002-12-31|2007-01-09|Laveille Kao Voss|Systems for anchoring a medical device in a body lumen|
    US20040133218A1|2003-01-07|2004-07-08|Charles Steven T.|Wound clamp|
    EP1596723A2|2003-02-04|2005-11-23|ev3 Sunnyvale, Inc.|Patent foramen ovale closure system|
    US20040176800A1|2003-03-07|2004-09-09|Paraschac Joseph Francis|Barbed closure device|
    CA2509720C|2003-04-22|2012-10-16|Sub-Q, Inc.|Puncture closure system with pin and pull technique|
    US20070084897A1|2003-05-20|2007-04-19|Shelton Frederick E Iv|Articulating surgical stapling instrument incorporating a two-piece e-beam firing mechanism|
    US9060770B2|2003-05-20|2015-06-23|Ethicon Endo-Surgery, Inc.|Robotically-driven surgical instrument with E-beam driver|
    US20050010241A1|2003-07-09|2005-01-13|Keith Milliman|Anastomosis instrument and method for performing same|
    US8308682B2|2003-07-18|2012-11-13|Broncus Medical Inc.|Devices for maintaining patency of surgically created channels in tissue|
    EP2345371B1|2003-08-14|2014-07-16|Loma Linda University Medical Center|Vascular wound closure device|
    US8137364B2|2003-09-11|2012-03-20|Abbott Laboratories|Articulating suturing device and method|
    CA2538329A1|2003-09-15|2005-03-31|Abbott Laboratories|Suture locking device and methods|
    US7462188B2|2003-09-26|2008-12-09|Abbott Laboratories|Device and method for suturing intracardiac defects|
    US7556647B2|2003-10-08|2009-07-07|Arbor Surgical Technologies, Inc.|Attachment device and methods of using the same|
    US8337522B2|2003-10-15|2012-12-25|St. Jude Medical Puerto Rico Llc|Vascular sealing device with locking hub|
    US8852229B2|2003-10-17|2014-10-07|Cordis Corporation|Locator and closure device and method of use|
    US7361183B2|2003-10-17|2008-04-22|Ensure Medical, Inc.|Locator and delivery device and method of use|
    US20050107820A1|2003-11-13|2005-05-19|Forsberg Andrew T.|Vascular puncture depth locator|
    US8128652B2|2003-11-13|2012-03-06|St. Jude Medical Puerto Rico Llc|Method and apparatus for sealing an internal tissue puncture incorporating a block and tackle|
    EP2260776A1|2003-11-21|2010-12-15|Vnus Medical Technologies, Inc.|Apparatus for treating the carotid artery|
    US7597705B2|2003-12-03|2009-10-06|St. Jude Medical Puerto Rico Llc|Vascular puncture seal anchor nest|
    US7621937B2|2003-12-03|2009-11-24|St. Jude Medical Puerto Rico LC|Vascular sealing device with high surface area sealing plug|
    US7449024B2|2003-12-23|2008-11-11|Abbott Laboratories|Suturing device with split arm and method of suturing tissue|
    US20050251204A1|2004-05-06|2005-11-10|Jurg Attinger|Wound clamp|
    US20050267520A1|2004-05-12|2005-12-01|Modesitt D B|Access and closure device and method|
    US20050267521A1|2004-05-13|2005-12-01|St. Jude Medical Puerto Rico B.V.|Collagen sponge for arterial sealing|
    EP1611850A1|2004-06-28|2006-01-04|Cardio Life Research S.A.|Occlusion and tight punction device for an anatomical structure|
    US7637925B2|2004-06-28|2009-12-29|Cardio Life Research S.A.|Surgical staple|
    US7678133B2|2004-07-10|2010-03-16|Arstasis, Inc.|Biological tissue closure device and method|
    US8215531B2|2004-07-28|2012-07-10|Ethicon Endo-Surgery, Inc.|Surgical stapling instrument having a medical substance dispenser|
    US20060058844A1|2004-09-13|2006-03-16|St. Jude Medical Puerto Rico B.V.|Vascular sealing device with locking system|
    US20060184199A1|2005-02-14|2006-08-17|O'leary Shawn|Apparatus and methods for reducing bleeding from a cannulation site|
    US20080249564A1|2005-03-11|2008-10-09|Hadba Ahmad R|Absorbable Surgical Fasteners|
    US7618436B2|2005-04-12|2009-11-17|St. Jude Medical Puerto Rico Llc|Tissue puncture closure device with scroll gear transmission tamping system|
    JP5225072B2|2005-04-22|2013-07-03|レックスメディカルリミテッドパートナーシップ|Left atrial appendage obturator|
    US8926654B2|2005-05-04|2015-01-06|Cordis Corporation|Locator and closure device and method of use|
    US8088144B2|2005-05-04|2012-01-03|Ensure Medical, Inc.|Locator and closure device and method of use|
    JP5140800B2|2005-05-12|2013-02-13|アルスタシス，インコーポレイテッド|Access and occlusion devices|
    DE202005009061U1|2005-05-31|2006-10-12|Karl Storz Gmbh & Co. Kg|Clip and clip setter for closing blood vessels|
    US8734362B2|2005-07-26|2014-05-27|Edward M. Boyle, JR.|Minimally invasive methods and apparatus|
    US20100114124A1|2005-08-03|2010-05-06|Brian Kelleher|Method and apparatus for partioning an organ within the body|
    US7883517B2|2005-08-08|2011-02-08|Abbott Laboratories|Vascular suturing device|
    US8083754B2|2005-08-08|2011-12-27|Abbott Laboratories|Vascular suturing device with needle capture|
    WO2007019016A1|2005-08-08|2007-02-15|Abbott Laboratories|Vascular suturing device|
    US20070060895A1|2005-08-24|2007-03-15|Sibbitt Wilmer L Jr|Vascular closure methods and apparatuses|
    US8758397B2|2005-08-24|2014-06-24|Abbott Vascular Inc.|Vascular closure methods and apparatuses|
    US9237891B2|2005-08-31|2016-01-19|Ethicon Endo-Surgery, Inc.|Robotically-controlled surgical stapling devices that produce formed staples having different lengths|
    US7934630B2|2005-08-31|2011-05-03|Ethicon Endo-Surgery, Inc.|Staple cartridges for forming staples having differing formed staple heights|
    US7669746B2|2005-08-31|2010-03-02|Ethicon Endo-Surgery, Inc.|Staple cartridges for forming staples having differing formed staple heights|
    US10159482B2|2005-08-31|2018-12-25|Ethicon Llc|Fastener cartridge assembly comprising a fixed anvil and different staple heights|
    US7673781B2|2005-08-31|2010-03-09|Ethicon Endo-Surgery, Inc.|Surgical stapling device with staple driver that supports multiple wire diameter staples|
    US8800838B2|2005-08-31|2014-08-12|Ethicon Endo-Surgery, Inc.|Robotically-controlled cable-based surgical end effectors|
    AT499882T|2005-10-05|2011-03-15|Univ Loma Linda Med|VASCULAR WOUND CLOSURE DEVICE|
    US20070106300A1|2005-11-08|2007-05-10|Alcon, Inc.|Surgical probe|
    US20070106317A1|2005-11-09|2007-05-10|Shelton Frederick E Iv|Hydraulically and electrically actuated articulation joints for surgical instruments|
    US20070142850A1|2005-12-15|2007-06-21|David Fowler|Compression anastomosis device|
    US8382794B2|2006-01-04|2013-02-26|St. Jude Medical Puerto Rico Llc|Balloon insertion apparatus and method of sealing a tissue puncture|
    US11207064B2|2011-05-27|2021-12-28|Cilag Gmbh International|Automated end effector component reloading system for use with a robotic system|
    US9861359B2|2006-01-31|2018-01-09|Ethicon Llc|Powered surgical instruments with firing system lockout arrangements|
    US8708213B2|2006-01-31|2014-04-29|Ethicon Endo-Surgery, Inc.|Surgical instrument having a feedback system|
    US20110290856A1|2006-01-31|2011-12-01|Ethicon Endo-Surgery, Inc.|Robotically-controlled surgical instrument with force-feedback capabilities|
    US8186555B2|2006-01-31|2012-05-29|Ethicon Endo-Surgery, Inc.|Motor-driven surgical cutting and fastening instrument with mechanical closure system|
    US8161977B2|2006-01-31|2012-04-24|Ethicon Endo-Surgery, Inc.|Accessing data stored in a memory of a surgical instrument|
    US20120292367A1|2006-01-31|2012-11-22|Ethicon Endo-Surgery, Inc.|Robotically-controlled end effector|
    US7845537B2|2006-01-31|2010-12-07|Ethicon Endo-Surgery, Inc.|Surgical instrument having recording capabilities|
    US11224427B2|2006-01-31|2022-01-18|Cilag Gmbh International|Surgical stapling system including a console and retraction assembly|
    US8820603B2|2006-01-31|2014-09-02|Ethicon Endo-Surgery, Inc.|Accessing data stored in a memory of a surgical instrument|
    US8763879B2|2006-01-31|2014-07-01|Ethicon Endo-Surgery, Inc.|Accessing data stored in a memory of surgical instrument|
    US7753904B2|2006-01-31|2010-07-13|Ethicon Endo-Surgery, Inc.|Endoscopic surgical instrument with a handle that can articulate with respect to the shaft|
    US7749249B2|2006-02-21|2010-07-06|Kardium Inc.|Method and device for closing holes in tissue|
    US8236010B2|2006-03-23|2012-08-07|Ethicon Endo-Surgery, Inc.|Surgical fastener and cutter with mimicking end effector|
    US8992422B2|2006-03-23|2015-03-31|Ethicon Endo-Surgery, Inc.|Robotically-controlled endoscopic accessory channel|
    US9408594B2|2006-03-25|2016-08-09|Aponos Medical Corporation|Self closing tissue fastener|
    US20070270688A1|2006-05-19|2007-11-22|Daniel Gelbart|Automatic atherectomy system|
    US8322455B2|2006-06-27|2012-12-04|Ethicon Endo-Surgery, Inc.|Manually driven surgical cutting and fastening instrument|
    US8449605B2|2006-06-28|2013-05-28|Kardium Inc.|Method for anchoring a mitral valve|
    US9119633B2|2006-06-28|2015-09-01|Kardium Inc.|Apparatus and method for intra-cardiac mapping and ablation|
    US9597063B2|2006-06-28|2017-03-21|Abbott Laboratories|Expandable introducer sheath to preserve guidewire access|
    US10028783B2|2006-06-28|2018-07-24|Kardium Inc.|Apparatus and method for intra-cardiac mapping and ablation|
    US8920411B2|2006-06-28|2014-12-30|Kardium Inc.|Apparatus and method for intra-cardiac mapping and ablation|
    US7837610B2|2006-08-02|2010-11-23|Kardium Inc.|System for improving diastolic dysfunction|
    US7842048B2|2006-08-18|2010-11-30|Abbott Laboratories|Articulating suture device and method|
    US20080097218A1|2006-08-24|2008-04-24|Boston Scientific Scimed, Inc.|Blood vessel puncture locating apparatus and method|
    US7749248B2|2006-09-18|2010-07-06|St. Jude Medical Puerto Rico Llc|Flexible tamping device|
    US10130359B2|2006-09-29|2018-11-20|Ethicon Llc|Method for forming a staple|
    US10568652B2|2006-09-29|2020-02-25|Ethicon Llc|Surgical staples having attached drivers of different heights and stapling instruments for deploying the same|
    US20080078802A1|2006-09-29|2008-04-03|Hess Christopher J|Surgical staples and stapling instruments|
    US8684253B2|2007-01-10|2014-04-01|Ethicon Endo-Surgery, Inc.|Surgical instrument with wireless communication between a control unit of a robotic system and remote sensor|
    US8459520B2|2007-01-10|2013-06-11|Ethicon Endo-Surgery, Inc.|Surgical instrument with wireless communication between control unit and remote sensor|
    US8652120B2|2007-01-10|2014-02-18|Ethicon Endo-Surgery, Inc.|Surgical instrument with wireless communication between control unit and sensor transponders|
    US20080169332A1|2007-01-11|2008-07-17|Shelton Frederick E|Surgical stapling device with a curved cutting member|
    US11039836B2|2007-01-11|2021-06-22|Cilag Gmbh International|Staple cartridge for use with a surgical stapling instrument|
    US20080173691A1|2007-01-24|2008-07-24|Medtronic Vascular, Inc.|Low-Profile Vascular Closure Systems and Methods of Using Same|
    US20080195135A1|2007-02-12|2008-08-14|Alcon, Inc.|Surgical Probe|
    US20090005809A1|2007-03-15|2009-01-01|Hess Christopher J|Surgical staple having a slidable crown|
    US8893946B2|2007-03-28|2014-11-25|Ethicon Endo-Surgery, Inc.|Laparoscopic tissue thickness and clamp load measuring devices|
    US8931682B2|2007-06-04|2015-01-13|Ethicon Endo-Surgery, Inc.|Robotically-controlled shaft based rotary drive systems for surgical instruments|
    US8534528B2|2007-06-04|2013-09-17|Ethicon Endo-Surgery, Inc.|Surgical instrument having a multiple rate directional switching mechanism|
    US7905380B2|2007-06-04|2011-03-15|Ethicon Endo-Surgery, Inc.|Surgical instrument having a multiple rate directional switching mechanism|
    US7832408B2|2007-06-04|2010-11-16|Ethicon Endo-Surgery, Inc.|Surgical instrument having a directional switching mechanism|
    US10307041B2|2007-06-08|2019-06-04|Medeon Biodesign, Inc.|Lens cover modification|
    EP2160214B1|2007-06-08|2018-10-31|Medeon Biodesign, Inc.|Devices for removal of debris from the objective lens of an endoscope|
    US7753245B2|2007-06-22|2010-07-13|Ethicon Endo-Surgery, Inc.|Surgical stapling instruments|
    US8408439B2|2007-06-22|2013-04-02|Ethicon Endo-Surgery, Inc.|Surgical stapling instrument with an articulatable end effector|
    US8574244B2|2007-06-25|2013-11-05|Abbott Laboratories|System for closing a puncture in a vessel wall|
    EP2166954A1|2007-07-13|2010-03-31|Rex Medical, L.P.|Vascular hole closure device|
    WO2009012473A2|2007-07-18|2009-01-22|Silk Road Medical, Inc.|Methods and systems for establishing retrograde carotid arterial blood flow|
    US8858490B2|2007-07-18|2014-10-14|Silk Road Medical, Inc.|Systems and methods for treating a carotid artery|
    US8568445B2|2007-08-21|2013-10-29|St. Jude Medical Puerto Rico Llc|Extra-vascular sealing device and method|
    US9456816B2|2007-09-12|2016-10-04|Transluminal Technologies, Llc|Closure device, deployment apparatus, and method of deploying a closure device|
    US8876861B2|2007-09-12|2014-11-04|Transluminal Technologies, Inc.|Closure device, deployment apparatus, and method of deploying a closure device|
    CA2704005C|2007-09-12|2013-02-05|Transluminal Technologies, Llc|Closure device, deployment apparatus, and method of deploying a closure device|
    US20090105744A1|2007-10-17|2009-04-23|Modesitt D Bruce|Methods for forming tracts in tissue|
    US8906011B2|2007-11-16|2014-12-09|Kardium Inc.|Medical device for use in bodily lumens, for example an atrium|
    US8556931B2|2007-12-17|2013-10-15|Abbott Laboratories|Methods for imaging a delivery system|
    US8840640B2|2007-12-31|2014-09-23|St. Jude Medical Puerto Rico Llc|Vascular closure device having an improved plug|
    US8333787B2|2007-12-31|2012-12-18|St. Jude Medical Puerto Rico Llc|Vascular closure device having a flowable sealing material|
    US9282953B2|2007-12-31|2016-03-15|St. Jude Medical Puerto Rico Llc|Systems and methods for locating and closing a tissue puncture|
    US8489172B2|2008-01-25|2013-07-16|Kardium Inc.|Liposuction system|
    ES2821762T3|2008-02-05|2021-04-27|Silk Road Medical Inc|Interventional catheter system|
    US8561870B2|2008-02-13|2013-10-22|Ethicon Endo-Surgery, Inc.|Surgical stapling instrument|
    US8573465B2|2008-02-14|2013-11-05|Ethicon Endo-Surgery, Inc.|Robotically-controlled surgical end effector system with rotary actuated closure systems|
    US7866527B2|2008-02-14|2011-01-11|Ethicon Endo-Surgery, Inc.|Surgical stapling apparatus with interlockable firing system|
    US8657174B2|2008-02-14|2014-02-25|Ethicon Endo-Surgery, Inc.|Motorized surgical cutting and fastening instrument having handle based power source|
    RU2493788C2|2008-02-14|2013-09-27|Этикон Эндо-Серджери, Инк.|Surgical cutting and fixing instrument, which has radio-frequency electrodes|
    US8752749B2|2008-02-14|2014-06-17|Ethicon Endo-Surgery, Inc.|Robotically-controlled disposable motor-driven loading unit|
    US8636736B2|2008-02-14|2014-01-28|Ethicon Endo-Surgery, Inc.|Motorized surgical cutting and fastening instrument|
    US8459525B2|2008-02-14|2013-06-11|Ethicon Endo-Sugery, Inc.|Motorized surgical cutting and fastening instrument having a magnetic drive train torque limiting device|
    US9179912B2|2008-02-14|2015-11-10|Ethicon Endo-Surgery, Inc.|Robotically-controlled motorized surgical cutting and fastening instrument|
    US8758391B2|2008-02-14|2014-06-24|Ethicon Endo-Surgery, Inc.|Interchangeable tools for surgical instruments|
    US8622274B2|2008-02-14|2014-01-07|Ethicon Endo-Surgery, Inc.|Motorized cutting and fastening instrument having control circuit for optimizing battery usage|
    US8584919B2|2008-02-14|2013-11-19|Ethicon Endo-Sugery, Inc.|Surgical stapling apparatus with load-sensitive firing mechanism|
    US7819298B2|2008-02-14|2010-10-26|Ethicon Endo-Surgery, Inc.|Surgical stapling apparatus with control features operable with one hand|
    US7861906B2|2008-02-14|2011-01-04|Ethicon Endo-Surgery, Inc.|Surgical stapling apparatus with articulatable components|
    US7793812B2|2008-02-14|2010-09-14|Ethicon Endo-Surgery, Inc.|Disposable motor-driven loading unit for use with a surgical cutting and stapling apparatus|
    US8070772B2|2008-02-15|2011-12-06|Rex Medical, L.P.|Vascular hole closure device|
    US8920462B2|2008-02-15|2014-12-30|Rex Medical, L.P.|Vascular hole closure device|
    US10390823B2|2008-02-15|2019-08-27|Ethicon Llc|End effector comprising an adjunct|
    US8920463B2|2008-02-15|2014-12-30|Rex Medical, L.P.|Vascular hole closure device|
    US20110029013A1|2008-02-15|2011-02-03|Mcguckin James F|Vascular Hole Closure Device|
    US8491629B2|2008-02-15|2013-07-23|Rex Medical|Vascular hole closure delivery device|
    US9226738B2|2008-02-15|2016-01-05|Rex Medical, L.P.|Vascular hole closure delivery device|
    US20090228040A1|2008-03-04|2009-09-10|Medtronic Vascular, Inc.|Mechanism and Method for Closing an Arteriotomy|
    US20090242609A1|2008-03-31|2009-10-01|Medtronic Vascular, Inc.|Vascular Puncture Closure Staple With Tip Protection|
    US20090287304A1|2008-05-13|2009-11-19|Kardium Inc.|Medical Device for Constricting Tissue or a Bodily Orifice, for example a mitral valve|
    US8979882B2|2008-07-21|2015-03-17|Arstasis, Inc.|Devices, methods, and kits for forming tracts in tissue|
    WO2010011696A1|2008-07-21|2010-01-28|Arstasis, Inc.|Devices and methods for forming tracts in tissue|
    EP2323566A2|2008-08-13|2011-05-25|Silk Road Medical, Inc.|Suture delivery device|
    US8574245B2|2008-08-13|2013-11-05|Silk Road Medical, Inc.|Suture delivery device|
    EP2430982B1|2008-08-26|2020-06-24|St. Jude Medical, Inc.|System for sealing percutaneous punctures|
    US7905381B2|2008-09-19|2011-03-15|Ethicon Endo-Surgery, Inc.|Surgical stapling instrument with cutting member arrangement|
    US9050083B2|2008-09-23|2015-06-09|Ethicon Endo-Surgery, Inc.|Motorized surgical instrument|
    US8210411B2|2008-09-23|2012-07-03|Ethicon Endo-Surgery, Inc.|Motor-driven surgical cutting instrument|
    US9386983B2|2008-09-23|2016-07-12|Ethicon Endo-Surgery, Llc|Robotically-controlled motorized surgical instrument|
    US9005230B2|2008-09-23|2015-04-14|Ethicon Endo-Surgery, Inc.|Motorized surgical instrument|
    US8608045B2|2008-10-10|2013-12-17|Ethicon Endo-Sugery, Inc.|Powered surgical cutting and stapling apparatus with manually retractable firing system|
    EP3695772A1|2008-11-18|2020-08-19|United States Endoscopy Group, Inc.|Adapter for attaching devices to endoscopes|
    US8239004B2|2008-12-17|2012-08-07|Abbott Laboratories|Methods for imaging an implant site|
    US8414577B2|2009-02-05|2013-04-09|Ethicon Endo-Surgery, Inc.|Surgical instruments and components for use in sterile environments|
    US8397971B2|2009-02-05|2013-03-19|Ethicon Endo-Surgery, Inc.|Sterilizable surgical instrument|
    US8517239B2|2009-02-05|2013-08-27|Ethicon Endo-Surgery, Inc.|Surgical stapling instrument comprising a magnetic element driver|
    US20110024477A1|2009-02-06|2011-02-03|Hall Steven G|Driven Surgical Stapler Improvements|
    US8453907B2|2009-02-06|2013-06-04|Ethicon Endo-Surgery, Inc.|Motor driven surgical fastener device with cutting member reversing mechanism|
    US8444036B2|2009-02-06|2013-05-21|Ethicon Endo-Surgery, Inc.|Motor driven surgical fastener device with mechanisms for adjusting a tissue gap within the end effector|
    US8052914B2|2009-02-20|2011-11-08|Boston Scientific Scimed, Inc.|Modified plug for arteriotomy closure|
    US8292918B2|2009-02-20|2012-10-23|Boston Scientific Scimed, Inc.|Composite plug for arteriotomy closure and method of use|
    US8317824B2|2009-02-20|2012-11-27|Boston Scientific Scimed, Inc.|Tissue puncture closure device|
    US9913634B2|2009-02-20|2018-03-13|Boston Scientific Scimed, Inc.|Locking element for vascular closure device|
    US8529598B2|2009-02-20|2013-09-10|Boston Scientific Scimed, Inc.|Tissue puncture closure device|
    US8375553B2|2009-02-20|2013-02-19|Boston Scientific Scimed, Inc.|Locking element for vascular closure device|
    JP2012526640A|2009-05-15|2012-11-01|アルスタシス，インコーポレイテッド|Apparatus, method and kit for forming pathways in tissue|
    US20110034802A1|2009-08-05|2011-02-10|Abbott Laboratories|Systems, methods, and apparatus for imaging an implantable device and methods for manufacturing|
    US20110054496A1|2009-08-27|2011-03-03|Md-Art, Inc.|Vascular clip|
    CN102665573B|2009-09-22|2015-09-16|阿尔斯塔西斯公司|For forming the device of pipeline in the tissue|
    WO2011041571A2|2009-10-01|2011-04-07|Kardium Inc.|Medical device, kit and method for constricting tissue or a bodily orifice, for example, a mitral valve|
    US10194904B2|2009-10-08|2019-02-05|Covidien Lp|Surgical staple and method of use|
    US8413872B2|2009-10-28|2013-04-09|Covidien Lp|Surgical fastening apparatus|
    CN102821673B|2009-11-10|2016-06-08|纽瓦西弗公司|Retractor systems|
    US8220688B2|2009-12-24|2012-07-17|Ethicon Endo-Surgery, Inc.|Motor-driven surgical cutting instrument with electric actuator directional control assembly|
    US8636655B1|2010-01-19|2014-01-28|Ronald Childs|Tissue retraction system and related methods|
    US8444673B2|2010-02-11|2013-05-21|Boston Scientific Scimed, Inc.|Automatic vascular closure deployment devices and methods|
    US9050066B2|2010-06-07|2015-06-09|Kardium Inc.|Closing openings in anatomical tissue|
    US9370353B2|2010-09-01|2016-06-21|Abbott Cardiovascular Systems, Inc.|Suturing devices and methods|
    US8663252B2|2010-09-01|2014-03-04|Abbott Cardiovascular Systems, Inc.|Suturing devices and methods|
    US8597340B2|2010-09-17|2013-12-03|Boston Scientific Scimed, Inc.|Torque mechanism actuated bioabsorbable vascular closure device|
    US20120078244A1|2010-09-24|2012-03-29|Worrell Barry C|Control features for articulating surgical device|
    US8733613B2|2010-09-29|2014-05-27|Ethicon Endo-Surgery, Inc.|Staple cartridge|
    US9517063B2|2012-03-28|2016-12-13|Ethicon Endo-Surgery, Llc|Movable member for use with a tissue thickness compensator|
    US9386988B2|2010-09-30|2016-07-12|Ethicon End-Surgery, LLC|Retainer assembly including a tissue thickness compensator|
    RU2013119928A|2010-09-30|2014-11-10|Этикон Эндо-Серджери, Инк.|A STAPLING SYSTEM CONTAINING A RETAINING MATRIX AND A LEVELING MATRIX|
    US9629814B2|2010-09-30|2017-04-25|Ethicon Endo-Surgery, Llc|Tissue thickness compensator configured to redistribute compressive forces|
    CN104321024B|2012-03-28|2017-05-24|伊西康内外科公司|Tissue thickness compensator comprising a plurality of layers|
    US9386984B2|2013-02-08|2016-07-12|Ethicon Endo-Surgery, Llc|Staple cartridge comprising a releasable cover|
    US10945731B2|2010-09-30|2021-03-16|Ethicon Llc|Tissue thickness compensator comprising controlled release and expansion|
    US8893949B2|2010-09-30|2014-11-25|Ethicon Endo-Surgery, Inc.|Surgical stapler with floating anvil|
    US20120080344A1|2010-09-30|2012-04-05|Ethicon Endo-Surgery, Inc.|Implantable fastener cartridge comprising a support retainer|
    US9332974B2|2010-09-30|2016-05-10|Ethicon Endo-Surgery, Llc|Layered tissue thickness compensator|
    US8746535B2|2010-09-30|2014-06-10|Ethicon Endo-Surgery, Inc.|Tissue thickness compensator comprising detachable portions|
    US9220501B2|2010-09-30|2015-12-29|Ethicon Endo-Surgery, Inc.|Tissue thickness compensators|
    US8940002B2|2010-09-30|2015-01-27|Kardium Inc.|Tissue anchor system|
    US9204880B2|2012-03-28|2015-12-08|Ethicon Endo-Surgery, Inc.|Tissue thickness compensator comprising capsules defining a low pressure environment|
    US9314246B2|2010-09-30|2016-04-19|Ethicon Endo-Surgery, Llc|Tissue stapler having a thickness compensator incorporating an anti-inflammatory agent|
    US9351730B2|2011-04-29|2016-05-31|Ethicon Endo-Surgery, Llc|Tissue thickness compensator comprising channels|
    US9301752B2|2010-09-30|2016-04-05|Ethicon Endo-Surgery, Llc|Tissue thickness compensator comprising a plurality of capsules|
    US10123798B2|2010-09-30|2018-11-13|Ethicon Llc|Tissue thickness compensator comprising controlled release and expansion|
    US9848875B2|2010-09-30|2017-12-26|Ethicon Llc|Anvil layer attached to a proximal end of an end effector|
    CN104379068B|2012-03-28|2017-09-22|伊西康内外科公司|Holding device assembly including tissue thickness compensation part|
    CA2834649C|2011-04-29|2021-02-16|Ethicon Endo-Surgery, Inc.|Staple cartridge comprising staples positioned within a compressible portion thereof|
    US9364233B2|2010-09-30|2016-06-14|Ethicon Endo-Surgery, Llc|Tissue thickness compensators for circular surgical staplers|
    US9055941B2|2011-09-23|2015-06-16|Ethicon Endo-Surgery, Inc.|Staple cartridge including collapsible deck|
    US8695866B2|2010-10-01|2014-04-15|Ethicon Endo-Surgery, Inc.|Surgical instrument having a power control circuit|
    US8603137B2|2010-11-01|2013-12-10|Abbott Cardiovascular Systems, Inc.|Methods and systems for establishing hemostasis relative to a puncture|
    JP5981930B2|2010-11-09|2016-08-31|トランスルミナル テクノロジーズ リミテッド ライアビリティー カンパニー|Specially designed magnesium-aluminum alloy and its use in medicine in hemodynamic environment|
    US8758402B2|2010-12-17|2014-06-24|Boston Scientific Scimed, Inc.|Tissue puncture closure device|
    USD777925S1|2012-01-20|2017-01-31|Kardium Inc.|Intra-cardiac procedure device|
    US9452016B2|2011-01-21|2016-09-27|Kardium Inc.|Catheter system|
    USD777926S1|2012-01-20|2017-01-31|Kardium Inc.|Intra-cardiac procedure device|
    CA2764494A1|2011-01-21|2012-07-21|Kardium Inc.|Enhanced medical device for use in bodily cavities, for example an atrium|
    US9486273B2|2011-01-21|2016-11-08|Kardium Inc.|High-density electrode-based medical device system|
    US8685047B2|2011-02-07|2014-04-01|Abbott Vascular, Inc.|Scaffold device for preventing tissue trauma|
    US9149265B2|2011-02-26|2015-10-06|Abbott Cardiovascular Systems, Inc.|Hinged tissue support device|
    US9072511B2|2011-03-25|2015-07-07|Kardium Inc.|Medical kit for constricting tissue or a bodily orifice, for example, a mitral valve|
    JP5763263B2|2011-04-08|2015-08-12|コビディエン エルピー|Flexible microwave catheter for natural or artificial lumens|
    US9198662B2|2012-03-28|2015-12-01|Ethicon Endo-Surgery, Inc.|Tissue thickness compensator having improved visibility|
    US9307972B2|2011-05-10|2016-04-12|Nuvasive, Inc.|Method and apparatus for performing spinal fusion surgery|
    US8709034B2|2011-05-13|2014-04-29|Broncus Medical Inc.|Methods and devices for diagnosing, monitoring, or treating medical conditions through an opening through an airway wall|
    WO2012158553A2|2011-05-13|2012-11-22|Broncus Technologies, Inc.|Methods and devices for excision of tissue|
    US9414822B2|2011-05-19|2016-08-16|Abbott Cardiovascular Systems, Inc.|Tissue eversion apparatus and tissue closure device and methods for use thereof|
    US9072535B2|2011-05-27|2015-07-07|Ethicon Endo-Surgery, Inc.|Surgical stapling instruments with rotatable staple deployment arrangements|
    WO2013023075A1|2011-08-09|2013-02-14|Cook General Biotechnology Llc|Vial useable in tissue extraction procedures|
    US9055932B2|2011-08-26|2015-06-16|Abbott Cardiovascular Systems, Inc.|Suture fastener combination device|
    US9050084B2|2011-09-23|2015-06-09|Ethicon Endo-Surgery, Inc.|Staple cartridge including collapsible deck arrangement|
    FR2982142B1|2011-11-07|2013-11-29|Synchro Medical|AGRAFE FOR OSTEOSYNTHESIS|
    WO2013078235A1|2011-11-23|2013-05-30|Broncus Medical Inc|Methods and devices for diagnosing, monitoring, or treating medical conditions through an opening through an airway wall|
    US9044230B2|2012-02-13|2015-06-02|Ethicon Endo-Surgery, Inc.|Surgical cutting and fastening instrument with apparatus for determining cartridge and firing motion status|
    US9138214B2|2012-03-02|2015-09-22|Abbott Cardiovascular Systems, Inc.|Suture securing systems, devices and methods|
    US9307989B2|2012-03-28|2016-04-12|Ethicon Endo-Surgery, Llc|Tissue stapler having a thickness compensator incorportating a hydrophobic agent|
    CN104334098B|2012-03-28|2017-03-22|伊西康内外科公司|Tissue thickness compensator comprising capsules defining a low pressure environment|
    US8864778B2|2012-04-10|2014-10-21|Abbott Cardiovascular Systems, Inc.|Apparatus and method for suturing body lumens|
    US8858573B2|2012-04-10|2014-10-14|Abbott Cardiovascular Systems, Inc.|Apparatus and method for suturing body lumens|
    US9011423B2|2012-05-21|2015-04-21|Kardium, Inc.|Systems and methods for selecting, activating, or selecting and activating transducers|
    US10827977B2|2012-05-21|2020-11-10|Kardium Inc.|Systems and methods for activating transducers|
    US9198592B2|2012-05-21|2015-12-01|Kardium Inc.|Systems and methods for activating transducers|
    US20130317481A1|2012-05-25|2013-11-28|Arstasis, Inc.|Vascular access configuration|
    US20130317438A1|2012-05-25|2013-11-28|Arstasis, Inc.|Vascular access configuration|
    US9241707B2|2012-05-31|2016-01-26|Abbott Cardiovascular Systems, Inc.|Systems, methods, and devices for closing holes in body lumens|
    US9101358B2|2012-06-15|2015-08-11|Ethicon Endo-Surgery, Inc.|Articulatable surgical instrument comprising a firing drive|
    US20140001231A1|2012-06-28|2014-01-02|Ethicon Endo-Surgery, Inc.|Firing system lockout arrangements for surgical instruments|
    US9119657B2|2012-06-28|2015-09-01|Ethicon Endo-Surgery, Inc.|Rotary actuatable closure arrangement for surgical end effector|
    US11202631B2|2012-06-28|2021-12-21|Cilag Gmbh International|Stapling assembly comprising a firing lockout|
    US9649111B2|2012-06-28|2017-05-16|Ethicon Endo-Surgery, Llc|Replaceable clip cartridge for a clip applier|
    US9289256B2|2012-06-28|2016-03-22|Ethicon Endo-Surgery, Llc|Surgical end effectors having angled tissue-contacting surfaces|
    US9028494B2|2012-06-28|2015-05-12|Ethicon Endo-Surgery, Inc.|Interchangeable end effector coupling arrangement|
    US9072536B2|2012-06-28|2015-07-07|Ethicon Endo-Surgery, Inc.|Differential locking arrangements for rotary powered surgical instruments|
    US9101385B2|2012-06-28|2015-08-11|Ethicon Endo-Surgery, Inc.|Electrode connections for rotary driven surgical tools|
    US9364230B2|2012-06-28|2016-06-14|Ethicon Endo-Surgery, Llc|Surgical stapling instruments with rotary joint assemblies|
    US9125662B2|2012-06-28|2015-09-08|Ethicon Endo-Surgery, Inc.|Multi-axis articulating and rotating surgical tools|
    US8747238B2|2012-06-28|2014-06-10|Ethicon Endo-Surgery, Inc.|Rotary drive shaft assemblies for surgical instruments with articulatable end effectors|
    US9204879B2|2012-06-28|2015-12-08|Ethicon Endo-Surgery, Inc.|Flexible drive member|
    US9561038B2|2012-06-28|2017-02-07|Ethicon Endo-Surgery, Llc|Interchangeable clip applier|
    WO2014025930A1|2012-08-09|2014-02-13|Silk Road Medical, Inc.|Suture delivery device|
    US9486132B2|2013-01-17|2016-11-08|Abbott Cardiovascular Systems, Inc.|Access device for accessing tissue|
    US10092292B2|2013-02-28|2018-10-09|Ethicon Llc|Staple forming features for surgical stapling instrument|
    JP6345707B2|2013-03-01|2018-06-20|エシコン・エンド−サージェリィ・インコーポレイテッドＥｔｈｉｃｏｎ Ｅｎｄｏ−Ｓｕｒｇｅｒｙ，Ｉｎｃ．|Surgical instrument with soft stop|
    US9554794B2|2013-03-01|2017-01-31|Ethicon Endo-Surgery, Llc|Multiple processor motor control for modular surgical instruments|
    JP6382235B2|2013-03-01|2018-08-29|エシコン・エンド−サージェリィ・インコーポレイテッドＥｔｈｉｃｏｎ Ｅｎｄｏ−Ｓｕｒｇｅｒｙ，Ｉｎｃ．|Articulatable surgical instrument with a conductive path for signal communication|
    US9345481B2|2013-03-13|2016-05-24|Ethicon Endo-Surgery, Llc|Staple cartridge tissue thickness sensor system|
    US9629629B2|2013-03-14|2017-04-25|Ethicon Endo-Surgey, LLC|Control systems for surgical instruments|
    US10470762B2|2013-03-14|2019-11-12|Ethicon Llc|Multi-function motor for a surgical instrument|
    US9572577B2|2013-03-27|2017-02-21|Ethicon Endo-Surgery, Llc|Fastener cartridge comprising a tissue thickness compensator including openings therein|
    US9795384B2|2013-03-27|2017-10-24|Ethicon Llc|Fastener cartridge comprising a tissue thickness compensator and a gap setting element|
    US9332984B2|2013-03-27|2016-05-10|Ethicon Endo-Surgery, Llc|Fastener cartridge assemblies|
    US9649110B2|2013-04-16|2017-05-16|Ethicon Llc|Surgical instrument comprising a closing drive and a firing drive operated from the same rotatable output|
    US9574644B2|2013-05-30|2017-02-21|Ethicon Endo-Surgery, Llc|Power module for use with a surgical instrument|
    MX369362B|2013-08-23|2019-11-06|Ethicon Endo Surgery Llc|Firing member retraction devices for powered surgical instruments.|
    US9808249B2|2013-08-23|2017-11-07|Ethicon Llc|Attachment portions for surgical instrument assemblies|
    US9301746B2|2013-10-11|2016-04-05|Abbott Cardiovascular Systems, Inc.|Suture-based closure with hemostatic tract plug|
    US9642620B2|2013-12-23|2017-05-09|Ethicon Endo-Surgery, Llc|Surgical cutting and stapling instruments with articulatable end effectors|
    US9549735B2|2013-12-23|2017-01-24|Ethicon Endo-Surgery, Llc|Fastener cartridge comprising a firing member including fastener transfer surfaces|
    US20150173756A1|2013-12-23|2015-06-25|Ethicon Endo-Surgery, Inc.|Surgical cutting and stapling methods|
    US9681870B2|2013-12-23|2017-06-20|Ethicon Llc|Articulatable surgical instruments with separate and distinct closing and firing systems|
    US9839428B2|2013-12-23|2017-12-12|Ethicon Llc|Surgical cutting and stapling instruments with independent jaw control features|
    US9724092B2|2013-12-23|2017-08-08|Ethicon Llc|Modular surgical instruments|
    US9962161B2|2014-02-12|2018-05-08|Ethicon Llc|Deliverable surgical instrument|
    CN106232029B|2014-02-24|2019-04-12|伊西康内外科有限责任公司|Fastening system including firing member locking piece|
    US20140166725A1|2014-02-24|2014-06-19|Ethicon Endo-Surgery, Inc.|Staple cartridge including a barbed staple.|
    US9913642B2|2014-03-26|2018-03-13|Ethicon Llc|Surgical instrument comprising a sensor system|
    US20150272580A1|2014-03-26|2015-10-01|Ethicon Endo-Surgery, Inc.|Verification of number of battery exchanges/procedure count|
    US9826977B2|2014-03-26|2017-11-28|Ethicon Llc|Sterilization verification circuit|
    US20150272557A1|2014-03-26|2015-10-01|Ethicon Endo-Surgery, Inc.|Modular surgical instrument system|
    US9877721B2|2014-04-16|2018-01-30|Ethicon Llc|Fastener cartridge comprising tissue control features|
    US10154904B2|2014-04-28|2018-12-18|Edwards Lifesciences Corporation|Intravascular introducer devices|
    WO2015175537A1|2014-05-16|2015-11-19|Silk Road Medical, Inc.|Vessel access and closure assist system and method|
    US10045781B2|2014-06-13|2018-08-14|Ethicon Llc|Closure lockout systems for surgical instruments|
    GB2543468B|2014-08-13|2021-11-03|Nuvasive Inc|Minimally disruptive retractor and associated methods for spinal surgery|
    US9724094B2|2014-09-05|2017-08-08|Ethicon Llc|Adjunct with integrated sensors to quantify tissue compression|
    BR112017004361A2|2014-09-05|2017-12-05|Ethicon Llc|medical overcurrent modular power supply|
    US10206677B2|2014-09-26|2019-02-19|Ethicon Llc|Surgical staple and driver arrangements for staple cartridges|
    BR112017005981A2|2014-09-26|2017-12-19|Ethicon Llc|surgical staplers and ancillary materials|
    US10076325B2|2014-10-13|2018-09-18|Ethicon Llc|Surgical stapling apparatus comprising a tissue stop|
    US9924944B2|2014-10-16|2018-03-27|Ethicon Llc|Staple cartridge comprising an adjunct material|
    US10517594B2|2014-10-29|2019-12-31|Ethicon Llc|Cartridge assemblies for surgical staplers|
    US11141153B2|2014-10-29|2021-10-12|Cilag Gmbh International|Staple cartridges comprising driver arrangements|
    US9844376B2|2014-11-06|2017-12-19|Ethicon Llc|Staple cartridge comprising a releasable adjunct material|
    USD847988S1|2015-11-13|2019-05-07|Access Closure, Inc.|Handle grip|
    USD865166S1|2015-11-13|2019-10-29|Access Closure, Inc.|Sheath adapter|
    USD843573S1|2015-11-13|2019-03-19|Access Closure, Inc.|Vascular closure apparatus|
    MA40946A|2014-11-14|2017-09-19|Access Closure Inc|APPARATUS AND METHODS FOR MAKING A VASCULAR PUNCTURE WATERTIGHT|
    US10722184B2|2014-11-17|2020-07-28|Kardium Inc.|Systems and methods for selecting, activating, or selecting and activating transducers|
    US10368936B2|2014-11-17|2019-08-06|Kardium Inc.|Systems and methods for selecting, activating, or selecting and activating transducers|
    US10736636B2|2014-12-10|2020-08-11|Ethicon Llc|Articulatable surgical instrument system|
    US9844374B2|2014-12-18|2017-12-19|Ethicon Llc|Surgical instrument systems comprising an articulatable end effector and means for adjusting the firing stroke of a firing member|
    US10188385B2|2014-12-18|2019-01-29|Ethicon Llc|Surgical instrument system comprising lockable systems|
    US9987000B2|2014-12-18|2018-06-05|Ethicon Llc|Surgical instrument assembly comprising a flexible articulation system|
    US9844375B2|2014-12-18|2017-12-19|Ethicon Llc|Drive arrangements for articulatable surgical instruments|
    US10085748B2|2014-12-18|2018-10-02|Ethicon Llc|Locking arrangements for detachable shaft assemblies with articulatable surgical end effectors|
    US9968355B2|2014-12-18|2018-05-15|Ethicon Llc|Surgical instruments with articulatable end effectors and improved firing beam support arrangements|
    US10117649B2|2014-12-18|2018-11-06|Ethicon Llc|Surgical instrument assembly comprising a lockable articulation system|
    US10226250B2|2015-02-27|2019-03-12|Ethicon Llc|Modular stapling assembly|
    US9931118B2|2015-02-27|2018-04-03|Ethicon Endo-Surgery, Llc|Reinforced battery for a surgical instrument|
    US10180463B2|2015-02-27|2019-01-15|Ethicon Llc|Surgical apparatus configured to assess whether a performance parameter of the surgical apparatus is within an acceptable performance band|
    US11154301B2|2015-02-27|2021-10-26|Cilag Gmbh International|Modular stapling assembly|
    US10687806B2|2015-03-06|2020-06-23|Ethicon Llc|Adaptive tissue compression techniques to adjust closure rates for multiple tissue types|
    US10617412B2|2015-03-06|2020-04-14|Ethicon Llc|System for detecting the mis-insertion of a staple cartridge into a surgical stapler|
    US9895148B2|2015-03-06|2018-02-20|Ethicon Endo-Surgery, Llc|Monitoring speed control and precision incrementing of motor for powered surgical instruments|
    US9808246B2|2015-03-06|2017-11-07|Ethicon Endo-Surgery, Llc|Method of operating a powered surgical instrument|
    US10045776B2|2015-03-06|2018-08-14|Ethicon Llc|Control techniques and sub-processor contained within modular shaft with select control processing from handle|
    US10052044B2|2015-03-06|2018-08-21|Ethicon Llc|Time dependent evaluation of sensor data to determine stability, creep, and viscoelastic elements of measures|
    US9901342B2|2015-03-06|2018-02-27|Ethicon Endo-Surgery, Llc|Signal and power communication system positioned on a rotatable shaft|
    US9924961B2|2015-03-06|2018-03-27|Ethicon Endo-Surgery, Llc|Interactive feedback system for powered surgical instruments|
    US9993248B2|2015-03-06|2018-06-12|Ethicon Endo-Surgery, Llc|Smart sensors with local signal processing|
    US10245033B2|2015-03-06|2019-04-02|Ethicon Llc|Surgical instrument comprising a lockable battery housing|
    US10433844B2|2015-03-31|2019-10-08|Ethicon Llc|Surgical instrument with selectively disengageable threaded drive systems|
    US10182818B2|2015-06-18|2019-01-22|Ethicon Llc|Surgical end effectors with positive jaw opening arrangements|
    US10617418B2|2015-08-17|2020-04-14|Ethicon Llc|Implantable layers for a surgical instrument|
    RU2725081C2|2015-08-26|2020-06-29|ЭТИКОН ЭлЭлСи|Strips with surgical staples allowing the presence of staples with variable properties and providing simple loading of the cartridge|
    US10357251B2|2015-08-26|2019-07-23|Ethicon Llc|Surgical staples comprising hardness variations for improved fastening of tissue|
    US10238390B2|2015-09-02|2019-03-26|Ethicon Llc|Surgical staple cartridges with driver arrangements for establishing herringbone staple patterns|
    US11213295B2|2015-09-02|2022-01-04|Cilag Gmbh International|Surgical staple configurations with camming surfaces located between portions supporting surgical staples|
    US10327769B2|2015-09-23|2019-06-25|Ethicon Llc|Surgical stapler having motor control based on a drive system component|
    US10085751B2|2015-09-23|2018-10-02|Ethicon Llc|Surgical stapler having temperature-based motor control|
    US10076326B2|2015-09-23|2018-09-18|Ethicon Llc|Surgical stapler having current mirror-based motor control|
    US10238386B2|2015-09-23|2019-03-26|Ethicon Llc|Surgical stapler having motor control based on an electrical parameter related to a motor current|
    US10363036B2|2015-09-23|2019-07-30|Ethicon Llc|Surgical stapler having force-based motor control|
    US10105139B2|2015-09-23|2018-10-23|Ethicon Llc|Surgical stapler having downstream current-based motor control|
    US10299878B2|2015-09-25|2019-05-28|Ethicon Llc|Implantable adjunct systems for determining adjunct skew|
    US10271849B2|2015-09-30|2019-04-30|Ethicon Llc|Woven constructs with interlocked standing fibers|
    US10478188B2|2015-09-30|2019-11-19|Ethicon Llc|Implantable layer comprising a constricted configuration|
    US10980539B2|2015-09-30|2021-04-20|Ethicon Llc|Implantable adjunct comprising bonded layers|
    US10368865B2|2015-12-30|2019-08-06|Ethicon Llc|Mechanisms for compensating for drivetrain failure in powered surgical instruments|
    US10265068B2|2015-12-30|2019-04-23|Ethicon Llc|Surgical instruments with separable motors and motor control circuits|
    US10292704B2|2015-12-30|2019-05-21|Ethicon Llc|Mechanisms for compensating for battery pack failure in powered surgical instruments|
    US11213293B2|2016-02-09|2022-01-04|Cilag Gmbh International|Articulatable surgical instruments with single articulation link arrangements|
    US10245030B2|2016-02-09|2019-04-02|Ethicon Llc|Surgical instruments with tensioning arrangements for cable driven articulation systems|
    US10448948B2|2016-02-12|2019-10-22|Ethicon Llc|Mechanisms for compensating for drivetrain failure in powered surgical instruments|
    US10258331B2|2016-02-12|2019-04-16|Ethicon Llc|Mechanisms for compensating for drivetrain failure in powered surgical instruments|
    US11224426B2|2016-02-12|2022-01-18|Cilag Gmbh International|Mechanisms for compensating for drivetrain failure in powered surgical instruments|
    US10413297B2|2016-04-01|2019-09-17|Ethicon Llc|Surgical stapling system configured to apply annular rows of staples having different heights|
    US10617413B2|2016-04-01|2020-04-14|Ethicon Llc|Closure system arrangements for surgical cutting and stapling devices with separate and distinct firing shafts|
    US11179150B2|2016-04-15|2021-11-23|Cilag Gmbh International|Systems and methods for controlling a surgical stapling and cutting instrument|
    US10405859B2|2016-04-15|2019-09-10|Ethicon Llc|Surgical instrument with adjustable stop/start control during a firing motion|
    US10357247B2|2016-04-15|2019-07-23|Ethicon Llc|Surgical instrument with multiple program responses during a firing motion|
    US10828028B2|2016-04-15|2020-11-10|Ethicon Llc|Surgical instrument with multiple program responses during a firing motion|
    US10456137B2|2016-04-15|2019-10-29|Ethicon Llc|Staple formation detection mechanisms|
    US10335145B2|2016-04-15|2019-07-02|Ethicon Llc|Modular surgical instrument with configurable operating mode|
    US10426467B2|2016-04-15|2019-10-01|Ethicon Llc|Surgical instrument with detection sensors|
    US10492783B2|2016-04-15|2019-12-03|Ethicon, Llc|Surgical instrument with improved stop/start control during a firing motion|
    US10368867B2|2016-04-18|2019-08-06|Ethicon Llc|Surgical instrument comprising a lockout|
    USD822206S1|2016-06-24|2018-07-03|Ethicon Llc|Surgical fastener|
    US11000278B2|2016-06-24|2021-05-11|Ethicon Llc|Staple cartridge comprising wire staples and stamped staples|
    USD826405S1|2016-06-24|2018-08-21|Ethicon Llc|Surgical fastener|
    USD847989S1|2016-06-24|2019-05-07|Ethicon Llc|Surgical fastener cartridge|
    USD850617S1|2016-06-24|2019-06-04|Ethicon Llc|Surgical fastener cartridge|
    US10945727B2|2016-12-21|2021-03-16|Ethicon Llc|Staple cartridge with deformable driver retention features|
    US10426471B2|2016-12-21|2019-10-01|Ethicon Llc|Surgical instrument with multiple failure response modes|
    US11134942B2|2016-12-21|2021-10-05|Cilag Gmbh International|Surgical stapling instruments and staple-forming anvils|
    US10588630B2|2016-12-21|2020-03-17|Ethicon Llc|Surgical tool assemblies with closure stroke reduction features|
    US10568625B2|2016-12-21|2020-02-25|Ethicon Llc|Staple cartridges and arrangements of staples and staple cavities therein|
    US10888322B2|2016-12-21|2021-01-12|Ethicon Llc|Surgical instrument comprising a cutting member|
    US10485543B2|2016-12-21|2019-11-26|Ethicon Llc|Anvil having a knife slot width|
    US10758230B2|2016-12-21|2020-09-01|Ethicon Llc|Surgical instrument with primary and safety processors|
    US10675026B2|2016-12-21|2020-06-09|Ethicon Llc|Methods of stapling tissue|
    US10588632B2|2016-12-21|2020-03-17|Ethicon Llc|Surgical end effectors and firing members thereof|
    US11179155B2|2016-12-21|2021-11-23|Cilag Gmbh International|Anvil arrangements for surgical staplers|
    JP2020501779A|2016-12-21|2020-01-23|エシコン エルエルシーＥｔｈｉｃｏｎ ＬＬＣ|Surgical stapling system|
    US10993715B2|2016-12-21|2021-05-04|Ethicon Llc|Staple cartridge comprising staples with different clamping breadths|
    US20180168650A1|2016-12-21|2018-06-21|Ethicon Endo-Surgery, Llc|Connection portions for disposable loading units for surgical stapling instruments|
    US10687810B2|2016-12-21|2020-06-23|Ethicon Llc|Stepped staple cartridge with tissue retention and gap setting features|
    US20180168619A1|2016-12-21|2018-06-21|Ethicon Endo-Surgery, Llc|Surgical stapling systems|
    US10695055B2|2016-12-21|2020-06-30|Ethicon Llc|Firing assembly comprising a lockout|
    US10898186B2|2016-12-21|2021-01-26|Ethicon Llc|Staple forming pocket arrangements comprising primary sidewalls and pocket sidewalls|
    US10542982B2|2016-12-21|2020-01-28|Ethicon Llc|Shaft assembly comprising first and second articulation lockouts|
    US10426449B2|2017-02-16|2019-10-01|Abbott Cardiovascular Systems, Inc.|Articulating suturing device with improved actuation and alignment mechanisms|
    US10888321B2|2017-06-20|2021-01-12|Ethicon Llc|Systems and methods for controlling velocity of a displacement member of a surgical stapling and cutting instrument|
    USD879809S1|2017-06-20|2020-03-31|Ethicon Llc|Display panel with changeable graphical user interface|
    US10881399B2|2017-06-20|2021-01-05|Ethicon Llc|Techniques for adaptive control of motor velocity of a surgical stapling and cutting instrument|
    US11090046B2|2017-06-20|2021-08-17|Cilag Gmbh International|Systems and methods for controlling displacement member motion of a surgical stapling and cutting instrument|
    US10368864B2|2017-06-20|2019-08-06|Ethicon Llc|Systems and methods for controlling displaying motor velocity for a surgical instrument|
    US10779820B2|2017-06-20|2020-09-22|Ethicon Llc|Systems and methods for controlling motor speed according to user input for a surgical instrument|
    US10327767B2|2017-06-20|2019-06-25|Ethicon Llc|Control of motor velocity of a surgical stapling and cutting instrument based on angle of articulation|
    US10813639B2|2017-06-20|2020-10-27|Ethicon Llc|Closed loop feedback control of motor velocity of a surgical stapling and cutting instrument based on system conditions|
    US11071554B2|2017-06-20|2021-07-27|Cilag Gmbh International|Closed loop feedback control of motor velocity of a surgical stapling and cutting instrument based on magnitude of velocity error measurements|
    US10881396B2|2017-06-20|2021-01-05|Ethicon Llc|Surgical instrument with variable duration trigger arrangement|
    US10646220B2|2017-06-20|2020-05-12|Ethicon Llc|Systems and methods for controlling displacement member velocity for a surgical instrument|
    USD890784S1|2017-06-20|2020-07-21|Ethicon Llc|Display panel with changeable graphical user interface|
    US10980537B2|2017-06-20|2021-04-20|Ethicon Llc|Closed loop feedback control of motor velocity of a surgical stapling and cutting instrument based on measured time over a specified number of shaft rotations|
    US10307170B2|2017-06-20|2019-06-04|Ethicon Llc|Method for closed loop control of motor velocity of a surgical stapling and cutting instrument|
    US10624633B2|2017-06-20|2020-04-21|Ethicon Llc|Systems and methods for controlling motor velocity of a surgical stapling and cutting instrument|
    USD879808S1|2017-06-20|2020-03-31|Ethicon Llc|Display panel with graphical user interface|
    US10390841B2|2017-06-20|2019-08-27|Ethicon Llc|Control of motor velocity of a surgical stapling and cutting instrument based on angle of articulation|
    US10993716B2|2017-06-27|2021-05-04|Ethicon Llc|Surgical anvil arrangements|
    US11090049B2|2017-06-27|2021-08-17|Cilag Gmbh International|Staple forming pocket arrangements|
    US20180368843A1|2017-06-27|2018-12-27|Ethicon Llc|Surgical firing member arrangements|
    US10772629B2|2017-06-27|2020-09-15|Ethicon Llc|Surgical anvil arrangements|
    USD851762S1|2017-06-28|2019-06-18|Ethicon Llc|Anvil|
    US10765427B2|2017-06-28|2020-09-08|Ethicon Llc|Method for articulating a surgical instrument|
    US10716614B2|2017-06-28|2020-07-21|Ethicon Llc|Surgical shaft assemblies with slip ring assemblies with increased contact pressure|
    US11083455B2|2017-06-28|2021-08-10|Cilag Gmbh International|Surgical instrument comprising an articulation system ratio|
    US10211586B2|2017-06-28|2019-02-19|Ethicon Llc|Surgical shaft assemblies with watertight housings|
    US10588633B2|2017-06-28|2020-03-17|Ethicon Llc|Surgical instruments with open and closable jaws and axially movable firing member that is initially parked in close proximity to the jaws prior to firing|
    USD854151S1|2017-06-28|2019-07-16|Ethicon Llc|Surgical instrument shaft|
    USD906355S1|2017-06-28|2020-12-29|Ethicon Llc|Display screen or portion thereof with a graphical user interface for a surgical instrument|
    USD869655S1|2017-06-28|2019-12-10|Ethicon Llc|Surgical fastener cartridge|
    US10903685B2|2017-06-28|2021-01-26|Ethicon Llc|Surgical shaft assemblies with slip ring assemblies forming capacitive channels|
    US10398434B2|2017-06-29|2019-09-03|Ethicon Llc|Closed loop velocity control of closure member for robotic surgical instrument|
    US10932772B2|2017-06-29|2021-03-02|Ethicon Llc|Methods for closed loop velocity control for robotic surgical instrument|
    US11007022B2|2017-06-29|2021-05-18|Ethicon Llc|Closed loop velocity control techniques based on sensed tissue parameters for robotic surgical instrument|
    US10258418B2|2017-06-29|2019-04-16|Ethicon Llc|System for controlling articulation forces|
    US10898183B2|2017-06-29|2021-01-26|Ethicon Llc|Robotic surgical instrument with closed loop feedback techniques for advancement of closure member during firing|
    USD907648S1|2017-09-29|2021-01-12|Ethicon Llc|Display screen or portion thereof with animated graphical user interface|
    USD917500S1|2017-09-29|2021-04-27|Ethicon Llc|Display screen or portion thereof with graphical user interface|
    US10743872B2|2017-09-29|2020-08-18|Ethicon Llc|System and methods for controlling a display of a surgical instrument|
    US10796471B2|2017-09-29|2020-10-06|Ethicon Llc|Systems and methods of displaying a knife position for a surgical instrument|
    US10729501B2|2017-09-29|2020-08-04|Ethicon Llc|Systems and methods for language selection of a surgical instrument|
    US10765429B2|2017-09-29|2020-09-08|Ethicon Llc|Systems and methods for providing alerts according to the operational state of a surgical instrument|
    USD907647S1|2017-09-29|2021-01-12|Ethicon Llc|Display screen or portion thereof with animated graphical user interface|
    US11134944B2|2017-10-30|2021-10-05|Cilag Gmbh International|Surgical stapler knife motion controls|
    US11090075B2|2017-10-30|2021-08-17|Cilag Gmbh International|Articulation features for surgical end effector|
    US10842490B2|2017-10-31|2020-11-24|Ethicon Llc|Cartridge body design with force reduction based on firing completion|
    US10779903B2|2017-10-31|2020-09-22|Ethicon Llc|Positive shaft rotation lock activated by jaw closure|
    US11006955B2|2017-12-15|2021-05-18|Ethicon Llc|End effectors with positive jaw opening features for use with adapters for electromechanical surgical instruments|
    US10743875B2|2017-12-15|2020-08-18|Ethicon Llc|Surgical end effectors with jaw stiffener arrangements configured to permit monitoring of firing member|
    US10779826B2|2017-12-15|2020-09-22|Ethicon Llc|Methods of operating surgical end effectors|
    US10869666B2|2017-12-15|2020-12-22|Ethicon Llc|Adapters with control systems for controlling multiple motors of an electromechanical surgical instrument|
    US10828033B2|2017-12-15|2020-11-10|Ethicon Llc|Handheld electromechanical surgical instruments with improved motor control arrangements for positioning components of an adapter coupled thereto|
    US10779825B2|2017-12-15|2020-09-22|Ethicon Llc|Adapters with end effector position sensing and control arrangements for use in connection with electromechanical surgical instruments|
    US10966718B2|2017-12-15|2021-04-06|Ethicon Llc|Dynamic clamping assemblies with improved wear characteristics for use in connection with electromechanical surgical instruments|
    US11071543B2|2017-12-15|2021-07-27|Cilag Gmbh International|Surgical end effectors with clamping assemblies configured to increase jaw aperture ranges|
    US10743874B2|2017-12-15|2020-08-18|Ethicon Llc|Sealed adapters for use with electromechanical surgical instruments|
    US11197670B2|2017-12-15|2021-12-14|Cilag Gmbh International|Surgical end effectors with pivotal jaws configured to touch at their respective distal ends when fully closed|
    US10687813B2|2017-12-15|2020-06-23|Ethicon Llc|Adapters with firing stroke sensing arrangements for use in connection with electromechanical surgical instruments|
    US11033267B2|2017-12-15|2021-06-15|Ethicon Llc|Systems and methods of controlling a clamping member firing rate of a surgical instrument|
    US10835330B2|2017-12-19|2020-11-17|Ethicon Llc|Method for determining the position of a rotatable jaw of a surgical instrument attachment assembly|
    US11020112B2|2017-12-19|2021-06-01|Ethicon Llc|Surgical tools configured for interchangeable use with different controller interfaces|
    US10729509B2|2017-12-19|2020-08-04|Ethicon Llc|Surgical instrument comprising closure and firing locking mechanism|
    USD910847S1|2017-12-19|2021-02-16|Ethicon Llc|Surgical instrument assembly|
    US11045270B2|2017-12-19|2021-06-29|Cilag Gmbh International|Robotic attachment comprising exterior drive actuator|
    US10716565B2|2017-12-19|2020-07-21|Ethicon Llc|Surgical instruments with dual articulation drivers|
    US11076853B2|2017-12-21|2021-08-03|Cilag Gmbh International|Systems and methods of displaying a knife position during transection for a surgical instrument|
    US11129680B2|2017-12-21|2021-09-28|Cilag Gmbh International|Surgical instrument comprising a projector|
    US20190192146A1|2017-12-21|2019-06-27|Ethicon Llc|Self-guiding stapling instrument|
    US11083458B2|2018-08-20|2021-08-10|Cilag Gmbh International|Powered surgical instruments with clutching arrangements to convert linear drive motions to rotary drive motions|
    US10779821B2|2018-08-20|2020-09-22|Ethicon Llc|Surgical stapler anvils with tissue stop features configured to avoid tissue pinch|
    US11207065B2|2018-08-20|2021-12-28|Cilag Gmbh International|Method for fabricating surgical stapler anvils|
    USD914878S1|2018-08-20|2021-03-30|Ethicon Llc|Surgical instrument anvil|
    US10856870B2|2018-08-20|2020-12-08|Ethicon Llc|Switching arrangements for motor powered articulatable surgical instruments|
    US10912559B2|2018-08-20|2021-02-09|Ethicon Llc|Reinforced deformable anvil tip for surgical stapler anvil|
    US10842492B2|2018-08-20|2020-11-24|Ethicon Llc|Powered articulatable surgical instruments with clutching and locking arrangements for linking an articulation drive system to a firing drive system|
    US11045192B2|2018-08-20|2021-06-29|Cilag Gmbh International|Fabricating techniques for surgical stapler anvils|
    US11039834B2|2018-08-20|2021-06-22|Cilag Gmbh International|Surgical stapler anvils with staple directing protrusions and tissue stability features|
    US11147551B2|2019-03-25|2021-10-19|Cilag Gmbh International|Firing drive arrangements for surgical systems|
    US11172929B2|2019-03-25|2021-11-16|Cilag Gmbh International|Articulation drive arrangements for surgical systems|
    US11147553B2|2019-03-25|2021-10-19|Cilag Gmbh International|Firing drive arrangements for surgical systems|
    US11219455B2|2019-06-28|2022-01-11|Cilag Gmbh International|Surgical instrument including a lockout key|
    US11224497B2|2019-06-28|2022-01-18|Cilag Gmbh International|Surgical systems with multiple RFID tags|
    US11051807B2|2019-06-28|2021-07-06|Cilag Gmbh International|Packaging assembly including a particulate trap|
    法律状态:
    2001-05-07| AS| Assignment|Owner name: INTEGRATED VASCULAR SYSTEMS, INC., CALIFORNIA Free format text: CHANGE OF NAME;ASSIGNOR:MEDICAL TECHNOLOGY GROUP, INC.;REEL/FRAME:011784/0170 Effective date: 20001122 |
    2001-08-06| STCF| Information on status: patent grant|Free format text: PATENTED CASE |
    2005-02-01| FPAY| Fee payment|Year of fee payment: 4 |
    2008-09-30| FPAY| Fee payment|Year of fee payment: 8 |
    2012-10-04| FPAY| Fee payment|Year of fee payment: 12 |
    优先权:
    申请号 | 申请日 | 专利标题
    US09/478,179|US6197042B1|2000-01-05|2000-01-05|Vascular sheath with puncture site closure apparatus and methods of use|
    US09/764,813|US6277140B2|2000-01-05|2001-01-16|Vascular sheath with puncture site closure apparatus and methods of use|US09/764,813| US6277140B2|2000-01-05|2001-01-16|Vascular sheath with puncture site closure apparatus and methods of use|
    US09/933,299| US6632238B2|2000-01-05|2001-08-20|Vascular sheath with puncture site closure apparatus and methods of use|
    [返回顶部]